[CAS NO. 469-38-5] Cycloartenol

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [469-38-5]

Catalog

HY-N7255

Brand

MCE

CAS

469-38-5

DESCRIPTION [469-38-5]

Overview

MDL	-
Molecular Weight	426.72
Molecular Formula	C30H50O
SMILES	CC1(C)[C@@H](O)CC[C@]2(C3)C43CC[C@]5(C)[C@@H]([C@H](C)CC/C=C(C)\C)CC[C@](C)5[C@]4([H])CC[C@@]12[H]

For research use only. We do not sell to patients.

Summary

Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development ^[1] ^[2] .

In Vitro

Cycloartenol inhibits the proliferation and the colony formation potential of the glioma U87 cells in a concentration-dependent manner. The antiproliferative effects are found to be due to induction of Sub-G1 cell cycle arrest and triggering of apoptosis. Cycloartenol also causes significant alteration in the expression of Bax and Bcl-2 ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL ( 11.72 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3435 mL	11.7173 mL	23.4346 mL
5 mM	0.4687 mL	2.3435 mL	4.6869 mL
10 mM	0.2343 mL	1.1717 mL	2.3435 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 0.5 mg/mL (1.17 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 0.5 mg/mL (1.17 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 0.5 mg/mL (1.17 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

9,19-Cyclolanost-24-en-3-ol, (3β)-

Cycloartenol

9,19-Cyclo-9β-lanost-24-en-3β-ol

1H,19H-Cyclopropa[9,10]cyclopenta[a]phenanthrene, 9,19-cyclolanost-24-en-3-ol deriv.

(3β)-9,19-Cyclolanost-24-en-3-ol

Handianol

9,19-Cyclo-24-lanosten-3β-ol

Cycloart-24-en-3β-ol

NSC 670193