[CAS NO. 469-59-0] Jervine

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PRODUCTS SPECIFICATIONS [469-59-0]

Catalog

HY-N0836

Brand

MCE

CAS

469-59-0

DESCRIPTION [469-59-0]

Overview

MDL	-
Molecular Weight	425.60
Molecular Formula	C27H39NO3
SMILES	O=C1[C@]2([H])[C@]3(C)C(C[C@@H](O)CC3)=CC[C@@]2([H])[C@]4([H])CC[C@]5(O[C@@]6([H])[C@@]([C@H]5C)([H])NC[C@@H](C)C6)C(C)=C41

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Biochem Biophys Res Commun. 2020 Dec 10;533(3):397-403.

Summary

Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC ₅₀ of 500-700 nM ^[1] . Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum . Jervine has anti-inflammatory and antioxidant properties ^[2] .

IC50 & Target

IC50: 500-700 nM (Hedgehog) ^[1]

In Vitro

Jervine (40 μM; 6, 12 and 24 hours) inhibits Akt phosphorylation ^[3] .
Jervine (40 μM; 2 hours) inhibits NF-jB activation decreased COX-2 overexpression and induced apoptosis ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis ^[1]

Cell Line:	HEL and TF1a cells
Concentration:	40 μM
Incubation Time:	6, 12 and 24 hours
Result:	Inhibited Akt phosphorylation.

In Vivo

Jervine (orally; 50-400 mg/kg) exerts 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague Dawley rats (180-200  g) ^[2]
Dosage:	50, 100, 200 and 400  mg/kg
Administration:	Orally
Result:	Exerted 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 1 mg/mL ( 2.35 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3496 mL	11.7481 mL	23.4962 mL
5 mM	---	---	---
10 mM	---	---	---

* Please refer to the solubility information to select the appropriate solvent.

References

Synonyms

Spiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-11(1H)-one, 2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11a,11b-hexadecahydro-3-hydroxy-3′,6′,10,11b-tetramethyl-, (2′R,3S,3′R,3′aS,6′S,6aS,6bS,7′aR,11aS,11bR)-

Jervine

Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3β,23β)-

(2′R,3S,3′R,3′aS,6′S,6aS,6bS,7′aR,11aS,11bR)-2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11a,11b-Hexadecahydro-3-hydroxy-3′,6′,10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-11(1H)-one

Jervin

Spiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-11(1H)-one, 2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11a,11b-hexadecahydro-3-hydroxy-3′,6′,10,11b-tetramethyl-, [3S-(3α,6aα,6bβ,9α(3′S*,3′aR*,6′R*,7′aS*),11aβ,11bα)]-

NSC 23898

NSC 7520