[CAS NO. 471-80-7] Steviol

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PRODUCTS SPECIFICATIONS [471-80-7]

Catalog

HY-N2057

Brand

MCE

CAS

471-80-7

DESCRIPTION [471-80-7]

Overview

MDL	MFCD00210558
Molecular Weight	318.45
Molecular Formula	C20H30O3
SMILES	C[C@@]1(C(O)=O)CCC[C@@]2(C)[C@@]3([H])[C@@]4(CC([C@@](CC3)(O)C4)=C)CC[C@]12[H]

For research use only. We do not sell to patients.

Summary

Steviol is a major metabolite of the sweetening compound stevioside. Steviol slows renal cyst growth by reducing AQP2 expression and promoting AQP2 degradation ^[1] .

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT05264636	Cargill\|INQUIS Clinical Research	Healthy\|Human Gut Microflora	February 11, 2022	Not Applicable
NCT05287906	Midwest Center for Metabolic and Cardiovascular Research\|Cargill	Overweight and Obesity\|Type 2 Diabetes Mellitus	April 15, 2022	Not Applicable
NCT02146183	Per Bendix Jeppesen\|University of Aarhus\|Aarhus University Hospital	Glycogen Depletion	September 2013	Not Applicable

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 314.02 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1402 mL	15.7011 mL	31.4021 mL
5 mM	0.6280 mL	3.1402 mL	6.2804 mL
10 mM	0.3140 mL	1.5701 mL	3.1402 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (7.85 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (7.85 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.85 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Noitem R, et al. Steviol slows renal cyst growth by reducing AQP2 expression and promoting AQP2 degradation. Biomed Pharmacother. 2018 May;101:754-762.

Synonyms

Kaur-16-en-18-oic acid, 13-hydroxy-, (4α)-

Kaur-16-en-18-oic acid, 13-hydroxy-

Steviol

(4α)-13-Hydroxykaur-16-en-18-oic acid

Hydroxydehydrostevic acid

13-Hydroxykaurenoic acid

(-)-Steviol

NSC 226902

Ent-13-hydroxykauran-16-en-19-oic acid

13-O-Glucosylsteviol