[CAS NO. 4774-24-7] Quipazine
PRODUCTS SPECIFICATIONS [4774-24-7]
DESCRIPTION [4774-24-7]
Overview
| MDL | MFCD00242605 |
|---|---|
| Molecular Weight | 213.28 |
| Molecular Formula | C13H15N3 |
| SMILES | C1(N2CCNCC2)=NC3=CC=CC=C3C=C1 |
Summary
Quipazine is a 5-HT agonist with a K i value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine shows antiviral activity against SARS-CoV-2 with an EC 50 of 31.64 μM. Quipazine behaves as a 5-HT3R agonist in peripheral models. Quipazine can be used for neurological disease research [1] [2] [3] [4] .
In Vitro
Quipazine shows binding efficacy to 5-HT1 and 5-HT2 with K
i
values of 230 nM
[3]
.
Quipazine displaces [3H]GR65630 from 5-HT3R in rat entorhinal cortex with a K
i
value of 1.4 nM
[3]
.
Quipazine shows antagonistic properties on the rat vagus nerve with pIC
50
value of 6.1, 6.49 and 6.17 for 5-HT2, 5-HT1 and inhibition of 5-HT release
[4]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Quipazine (2.5, 5 and 7.5 mg/kg, one dose for once; i.p.) affects dietary self-selection of different macronutrient diets in male and female rats [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
References
- [1] Mok E, et al. Effect of quipazine, a selective 5-HT3 agonist, on dietary self-selection of different macronutrient diets in male and female rats. Appetite. 2000 Jun;34(3):313-25.
- [2] Günther S, et al. X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science. 2021 May 7;372(6542):642-646.
- [3] Glennon RA, et al. 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80.
- [4] Ireland SJ, Tyers MB. Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve. Br J Pharmacol. 1987 Jan;90(1):229-38.
Synonyms