[CAS NO. 480-66-0] Phloracetophenone

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PRODUCTS SPECIFICATIONS [480-66-0]

Catalog

HY-W008226

Brand

MCE

CAS

480-66-0

DESCRIPTION [480-66-0]

Overview

MDL	MFCD00002287
Molecular Weight	168.15
Molecular Formula	C8H8O4
SMILES	CC(=O)C1=C(O)C=C(O)C=C1O

For research use only. We do not sell to patients.

Summary

Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase ( CYP7A1 ) activity ^[1] . Phloracetophenone stimulats bile secretion mediated through Mrp2 ^[2] .

IC50 & Target

Cholesterol 7α-hydroxylase ^[1] , Mrp2 ^[2]

In Vitro

Phloracetophenone (2,4,6-trihydroxyacetophenone) is a cholesterol-lowering agent, enhances cholesterol 7α-hydroxylase (CYP7A1) activity, and elevates CYP7A1 mRNA level ^[1] .
Phloracetophenone (1, 2, and 4 μmol/min) immediately and dose-dependently increases bile acid-independent bile flow in the isolated perfused rat liver ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Phloracetophenone (2,4,6-trihydroxyacetophenone; 125 or 250 μmol/kg, intraduodenal injection) shows choleretic activity requiring multidrug resistance protein-2 (Mrp2) in rats. Phloracetophenone (40 μmol/min) partially prevents the E2-17G induced cholestasis ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 148.68 mM ; Need ultrasonic)

H ₂ O : 2 mg/mL ( 11.89 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.9471 mL	29.7354 mL	59.4707 mL
5 mM	1.1894 mL	5.9471 mL	11.8941 mL
10 mM	0.5947 mL	2.9735 mL	5.9471 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1.25 mg/mL (7.43 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1.25 mg/mL (7.43 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1.25 mg/mL (7.43 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Ethanone, 1-(2,4,6-trihydroxyphenyl)-

Phloroacetophenone

Acetophenone, 2′,4′,6′-trihydroxy-

1-(2,4,6-Trihydroxyphenyl)ethanone

Phloracetophenone

Acetophloroglucine

2′,4′,6′-Trihydroxyacetophenone

Acetylphloroglucinol

Phloracetophene

2-Acetyl-1,3,5-trihydroxybenzene

NSC 54927

1-(2,4,6-Trihydroxyphenyl)ethan-1-one

2-Acetyl-1,3,5-benzenetriol

2-Acetylphloroglucinol