[CAS NO. 483367-10-8] Purmorphamine
PRODUCTS SPECIFICATIONS [483367-10-8]
DESCRIPTION [483367-10-8]
Overview
| MDL | MFCD09037557 |
|---|---|
| Molecular Weight | 520.62 |
| Molecular Formula | C31H32N6O2 |
| SMILES | N1(C2=CC=C(NC3=NC(OC4=CC=CC5=C4C=CC=C5)=NC6=C3N=CN6C7CCCCC7)C=C2)CCOCC1 |
10 Publications Citing Use of MCE
- [1]Mil Med Res. 2020 Nov 1;7(1):52.
- [2]Mil Med Res. 2020 Sep 6;7(1):42.
- [3]J Exp Clin Cancer Res. 2018 Nov 27;37(1):287.
- [4]Pharmacol Res. 2021 Jan 26;105460.
- [5]Cancer Med. 2018 Nov;7(11):5704-5715.
- [6]Burns Trauma. 2019 Sep 23;7:29.
- [7]Biochem Biophys Res Commun. 12 August 2021.
- [8]Med Oncol. 2021 Mar 17;38(4):41.
- [9]Oncol Lett. 2019 Sep;18(3):3081-3091.
- [10]Patent. US20180263995A1.
Summary
Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a smoothened/Smo receptor agonist with an EC 50 of 1 μM [1] .
In Vitro
Purmorphamine (GMP) (1.5 μM, 1 week) can generate embryoid bodies (EBs) from human iPS cells (hiPS2) and hESCs (HSF1)
[1]
.
Purmorphamine (GMP) (1.5 μM) converts hPSCs to NKX2-1 positive MGE cells
[2]
.
Purmorphamine (GMP) (2 μM, day 28-35) promotes ventralization of the brain spheroids in differentiation process from hiPSCs
[3]
.
Purmorphamine (GMP) (1 μM) together with retinoic acid (RA, 2 μM) promotes hiPSC differentiation into functional neural tissue, indicated by the expression of neuronal marker β-tubulin III (βT-III)
[4]
.
Purmorphamine (GMP) (day5-7) induces hESCs differentiation into dopaminergic (DA) neurons
[5]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Karumbayaram S, et al. Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells. 2009 Apr;27(4):806-11.
- [2] Hu Y, et al. Directed differentiation of basal forebrain cholinergic neurons from human pluripotent stem cells. J Neurosci Methods. 2016 Jun 15;266:42-9.
- [3] Hua T, et al. Phenotypic, metabolic, and biogenesis properties of human stem cell-derived cerebellar spheroids. Sci Rep. 2022 Jul 27;12(1):12880.
- [4] Sharma R, et al. 3D Bioprinting Pluripotent Stem Cell Derived Neural Tissues Using a Novel Fibrin Bioink Containing Drug Releasing Microspheres. Front Bioeng Biotechnol. 2020 Feb 11;8:57.
- [5] Sundberg M, et al. Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons. Stem Cells. 2013 Aug;31(8):1548-62.
Synonyms