[CAS NO. 487-11-6] Elemicin

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PRODUCTS SPECIFICATIONS [487-11-6]

Catalog

HY-N6807

Brand

MCE

CAS

487-11-6

DESCRIPTION [487-11-6]

Overview

MDL	-
Molecular Weight	208.25
Molecular Formula	C12H16O3
SMILES	C=CCC1=CC(OC)=C(OC)C(OC)=C1

For research use only. We do not sell to patients.

Summary

Elemicin is a alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin is one of the main components in aromatic food and has antimicrobial, antioxidant, and antiviral activities. Elemicin possesses genotoxicity and carcinogenicity ^[1] .

IC50 & Target

SCD1 ^[1]

Appearance

Liquid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 250 mg/mL ( 1200.48 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8019 mL	24.0096 mL	48.0192 mL
5 mM	0.9604 mL	4.8019 mL	9.6038 mL
10 mM	0.4802 mL	2.4010 mL	4.8019 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 6.25 mg/mL (30.01 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 6.25 mg/mL (30.01 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 6.25 mg/mL (30.01 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Yang XN, et al. Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1. Chem Res Toxicol. 2019 Sep 10.

Synonyms

Benzene, 1,2,3-trimethoxy-5-(2-propen-1-yl)-

Elemicin

Benzene, 5-allyl-1,2,3-trimethoxy-

Benzene, 1,2,3-trimethoxy-5-(2-propenyl)-

1,2,3-Trimethoxy-5-(2-propen-1-yl)benzene

3,4,5-Trimethoxyallylbenzene

4-Allyl-1,2,6-trimethoxybenzene

5-(Prop-2-enyl)-1,2,3-trimethoxybenzene

1-Allyl-3,4,5-trimethoxybenzene

1,2,3-Trimethoxy-5-(2-propenyl)benzene

5-Allyl-1,2,3-trimethoxybenzene

1-(3,4,5-Trimethoxyphenyl)-2-propene

NSC 16704