[CAS NO. 490-31-3] Robinetin

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PRODUCTS SPECIFICATIONS [490-31-3]

Catalog

HY-N1347

Brand

MCE

CAS

490-31-3

DESCRIPTION [490-31-3]

Overview

MDL	MFCD00016783
Molecular Weight	302.24
Molecular Formula	C15H10O7
SMILES	O=C1C(O)=C(C2=CC(O)=C(O)C(O)=C2)OC3=CC(O)=CC=C13

For research use only. We do not sell to patients.

Summary

Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation ^[1] ^[2] ^[3] ^[4] ^[5] .

In Vitro

Robinetin (0.1-10 μM; 1 h) inhibits HIV integrase cleavage and integration in a dose-dependent manner ^[1] .
Robinetin inhibits the DNA synthesis in Proteus vulgaris , and the RNA synthesis in S. aureus ^[2] .
Robinetin (100-200 or 25 μM; 1 or 72 h) inhibits egg yolk phosphatidylcholine (EYPC) membrane lipid peroxidation and hemoglobin A (HbA) glycosylation with high efficiency ^[3] .
Robinetin exhibits photo-induced excited-state intramolecular proton transfer resulting in ‘two color’ (in ‘blue-violet’ and ‘yellow-green’ regions) fluorescence characteristic of flavonols, the relative contributions between the two colors being strongly modulated by the local environment of the fluorophore ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 120 mg/mL ( 397.04 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3086 mL	16.5431 mL	33.0863 mL
5 mM	0.6617 mL	3.3086 mL	6.6173 mL
10 mM	0.3309 mL	1.6543 mL	3.3086 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 3 mg/mL (9.93 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 3 mg/mL (9.93 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

4H-1-Benzopyran-4-one, 3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-

Robinetin

Flavone, 3,3′,4′,5′,7-pentahydroxy-

3,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one

Norkanugin

3,3′,4′,5′,7-Pentahydroxyflavone

3,7,3′,4′,5′-Pentahydroxyflavone

NSC 407331

NSC 656274

3,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one

3,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one