[CAS NO. 490-78-8] 2,5-Dihydroxyacetophenone

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PRODUCTS SPECIFICATIONS [490-78-8]

Catalog

HY-W001174

Brand

MCE

CAS

490-78-8

DESCRIPTION [490-78-8]

Overview

MDL	MFCD00002343
Molecular Weight	152.15
Molecular Formula	C8H8O3
SMILES	CC(C1=CC(O)=CC=C1O)=O

For research use only. We do not sell to patients.

Summary

2,5-Dihydroxyacetophenone, isolated from Rehmannia glutinosa , inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways ^[1] .

IC50 & Target

ERK1

ERK2

NF-κB

In Vitro

2,5-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression and significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 via the down-regulation of their mRNA expression in LPS-stimulated RAW264.7 cells. 2,5-Dihydroxyacetophenone potently inhibits the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-κB (NF-κB) p65 in LPS-stimulated cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 657.25 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.5725 mL	32.8623 mL	65.7246 mL
5 mM	1.3145 mL	6.5725 mL	13.1449 mL
10 mM	0.6572 mL	3.2862 mL	6.5725 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (16.43 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Han Y, et al. 2,5-dihydroxyacetophenone isolated from Preparata inhibits inflammatoryresponses in lipopolysaccharide-stimulated RAW264.7 macrophages. J Med Food. 2012 Jun;15(6):505-10.

Synonyms

Ethanone, 1-(2,5-dihydroxyphenyl)-

Acetophenone, 2′,5′-dihydroxy-

1-(2,5-Dihydroxyphenyl)ethanone

Quinacetophenone

2-Acetylhydroquinone

2′,5′-Dihydroxyacetophenone

1-Acetyl-2,5-dihydroxybenzene

2,5-Dihydroxy-1-acetylbenzene

2-Acetyl-1,4-benzenediol

NSC 3759

1-(2,5-Dihydroxyphenyl)ethan-1-one