[CAS NO. 498-02-2] Apocynin

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PRODUCTS SPECIFICATIONS [498-02-2]

Catalog

HY-N0088

Brand

MCE

CAS

498-02-2

DESCRIPTION [498-02-2]

Overview

MDL	MFCD00008747
Molecular Weight	166.17
Molecular Formula	C9H10O3
SMILES	CC(C1=CC=C(O)C(OC)=C1)=O

For research use only. We do not sell to patients.

12 Publications Citing Use of MCE

Summary

Apocynin is a selective NADPH-oxidase inhibitor with an IC ₅₀ of 10 μM.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT03680404	The University of Texas at Arlington	Cardiovascular Diseases\|Cardiovascular Risk Factor\|Vasoconstriction	October 1, 2018	Phase 1
NCT03680573	The University of Texas at Arlington	Cardiovascular Diseases\|Cardiovascular Risk Factor\|Vasoconstriction	January 8, 2018	Phase 1
NCT03680638	The University of Texas at Arlington	Cardiovascular Diseases\|Cardiovascular Risk Factor\|Vasodilation	September 7, 2016	Phase 1
NCT00992667	Medical University of Lodz\|Ministry of Science and Higher Education, Poland	Bronchial Asthma	June 2008	Phase 1
NCT01402297	Medical University of Lodz\|Ministry of Science and Higher Education, Poland	Chronic Obstructive Pulmonary Disease	October 2010	Phase 1

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 601.79 mM )

H ₂ O : ≥ mg/mL

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.0179 mL	30.0897 mL	60.1793 mL
5 mM	1.2036 mL	6.0179 mL	12.0359 mL
10 mM	0.6018 mL	3.0090 mL	6.0179 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Ethanone, 1-(4-hydroxy-3-methoxyphenyl)-

Acetophenone, 4′-hydroxy-3′-methoxy-

1-(4-Hydroxy-3-methoxyphenyl)ethanone

Acetoguaiacone

Acetovanillone

Apocynin

Apocynine

4-Acetyl-2-methoxyphenol

3′-Methoxy-4′-hydroxyacetophenone

4′-Hydroxy-3′-methoxyacetophenone

Acetoguaiacon

4-Hydroxy-3-methoxyphenyl methyl ketone

2-Methoxy-4-acetylphenol

4-Acetylguaiacol

Acetoguaicone

NSC 209524

NSC 2146

3-Methoxy-4-hydroxyphenylethanone

Acetoguaiacol

1-(4-Hydroxy-3-methoxyphenyl)ethan-1-one

4-Acetyl-1-hydroxy-2-methoxybenzene