[CAS NO. 499-75-2] Carvacrol

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PRODUCTS SPECIFICATIONS [499-75-2]

Catalog

HY-N0711

Brand

MCE

CAS

499-75-2

DESCRIPTION [499-75-2]

Overview

MDL	MFCD00002236
Molecular Weight	150.22
Molecular Formula	C10H14O
SMILES	OC1=CC(C(C)C)=CC=C1C

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Elife. 2021 Apr 20;10:e68128.

Summary

Carvacrol is a monoterpenoid phenol isolated from Thymus mongolicus Ronn. , with antioxidant, anti-inflammatory and anticancer properties. Carvacrol causes cell cycle arrest in G0/G1, downregulates Notch-1 , and Jagged-1, and induces apoptosis ^[1] .

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT05445089	Instituto Venezolano de Investigaciones Cientificas	COVID-19\|COVID-19 Pneumonia\|COVID-19 Respiratory Infection\|COVID-19 Acute Respiratory Distress Syndrome\|COVID-19 Lower Respiratory Infection	August 1, 2020	Phase 2\|Phase 3

Appearance

Liquid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 665.69 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.6569 mL	33.2845 mL	66.5690 mL
5 mM	1.3314 mL	6.6569 mL	13.3138 mL
10 mM	0.6657 mL	3.3285 mL	6.6569 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (16.64 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (16.64 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (16.64 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Khan F, et al. Carvacrol Induced Program Cell Death and Cell Cycle Arrest in Androgen-Independent Human Prostate Cancer Cells via Inhibition of Notch Signaling. Anticancer Agents Med Chem. 2019 Jul 31.

Synonyms

Phenol, 2-methyl-5-(1-methylethyl)-

Carvacrol

2-Methyl-5-(1-methylethyl)phenol

Antioxine

p-Cymen-2-ol

2-Hydroxy-p-cymene

2-Methyl-5-isopropylphenol

5-Isopropyl-2-methylphenol

5-Isopropyl-o-cresol

6-Methyl-3-isopropylphenol

2-Hydroxy-1-methyl-4-(1-methylethyl)benzene

3-Isopropyl-6-methylphenol

Isopropyl o-cresol

Isothymol

NSC 6188

Dentol

2-Methyl-5-(propan-2-yl)phenol