[CAS NO. 499-80-9] 2,4-PDCA

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PRODUCTS SPECIFICATIONS [499-80-9]

Catalog

HY-W017132

Brand

MCE

CAS

499-80-9

DESCRIPTION [499-80-9]

Overview

MDL	MFCD00006296
Molecular Weight	167.12
Molecular Formula	C7H5NO4
SMILES	O=C(C1=NC=CC(C(O)=O)=C1)O

For research use only. We do not sell to patients.

Summary

2,4-PDCA (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenase , including JmjC domain-containing family of histone demethylases (JHDMs) . 2,4-PDCA is a target chemical in the field of bio-based plastics ^[1] ^[2] ^[3] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 598.37 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.9837 mL	29.9186 mL	59.8372 mL
5 mM	1.1967 mL	5.9837 mL	11.9674 mL
10 mM	0.5984 mL	2.9919 mL	5.9837 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (14.96 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (14.96 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (14.96 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

2,4-Pyridinedicarboxylic acid

Lutidinic acid

2,4-Dicarboxylpyridine

2,4-Lutidinic acid

NSC 403248