[CAS NO. 503-49-1] Meglutol

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PRODUCTS SPECIFICATIONS [503-49-1]

Catalog

HY-B1189

Brand

MCE

CAS

503-49-1

DESCRIPTION [503-49-1]

Overview

MDL	MFCD00002712
Molecular Weight	162.14
Molecular Formula	C6H10O5
SMILES	O=C(O)CC(C)(O)CC(O)=O

For research use only. We do not sell to patients.

Summary

Meglutol is an antilipemic agent which lowers cholesterol , triglycerides, serum beta-lipoproteins and phospholipids , and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol .

IC50 & Target

Human Endogenous Metabolite

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 1541.88 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.1675 mL	30.8375 mL	61.6751 mL
5 mM	1.2335 mL	6.1675 mL	12.3350 mL
10 mM	0.6168 mL	3.0838 mL	6.1675 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (12.83 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (12.83 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (12.83 mM); Clear solution

* All of the co-solvents are available by MCE.

Synonyms

Pentanedioic acid, 3-hydroxy-3-methyl-

Glutaric acid, 3-hydroxy-3-methyl-

3-Hydroxy-3-methylpentanedioic acid

3-Hydroxy-3-methylglutaric acid

β-Hydroxy-β-methylglutaric acid

Meglutol

3-Methyl-3-hydroxyglutaric acid

Dicrotalic acid

CB 337

Mevalon

HMGA

Lipoglutaren

Medroglutaric acid

HMG

NSC 361411

3-Methyl-3-hydroxypentanedioic acid