[CAS NO. 50773-41-6] Polyphyllin I

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PRODUCTS SPECIFICATIONS [50773-41-6]

Catalog

HY-N0047

Brand

MCE

CAS

50773-41-6

DESCRIPTION [50773-41-6]

Overview

MDL	-
Molecular Weight	855.02
Molecular Formula	C44H70O16
SMILES	C[C@H](CC1)CO[C@]21O[C@@]3([H])C[C@@]4([H])[C@@]5([H])[C@]([C@](CC[C@H](O[C@]6([H])O[C@H](CO)[C@@H](O[C@]7([H])O[C@@H](CO)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O[C@@]8([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)C9)(C)C9=CC5)([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]FASEB J. 2020 Dec;34(12):16414-16431.

Summary

Polyphyllin I is a bioactive constituent extracted from Paris polyphylla , has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy , G2/M phase arrest and apoptosis ^[1] ^[2] ^[3] .

IC50 & Target

JNK signaling ^[2]
PDK1/Akt/mTOR signaling ^[3]

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 116.96 mM ; Need ultrasonic)

H ₂ O : < 0.1 mg/mL (ultrasonic) (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1696 mL	5.8478 mL	11.6956 mL
5 mM	0.2339 mL	1.1696 mL	2.3391 mL
10 mM	0.1170 mL	0.5848 mL	1.1696 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 0.83 mg/mL (0.97 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 0.83 mg/mL (0.97 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 0.83 mg/mL (0.97 mM); Clear solution

* All of the co-solvents are available by MCE.