[CAS NO. 508186-14-9] Ac-CoA Synthase Inhibitor1

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PRODUCTS SPECIFICATIONS [508186-14-9]

Catalog

HY-104032

Brand

MCE

CAS

508186-14-9

DESCRIPTION [508186-14-9]

Overview

MDL	MFCD03232237
Molecular Weight	410.51
Molecular Formula	C20H18N4O2S2
SMILES	O=C(NCCOC)NC1=CC=C2N=C(C3=CC=CS3)C(C4=CC=CS4)=NC2=C1

For research use only. We do not sell to patients.

Summary

Ac-CoA Synthase Inhibitor1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC ₅₀ of 0.6 µM ^[1] . Ac-CoA Synthase Inhibitor1 inhibits the respiratory syncytial virus (RSV) ^[2] .

In Vitro

Ac-CoA Synthase Inhibitor1 inhibits cellular [ ¹⁴ C]acetate uptake into both lipids and histones with an IC ₅₀ of 5 µM. Ac-CoA Synthase Inhibitor1 inhibits the ability of HepG2 cells to incorporate [ ¹⁴ C]acetate into lipids with IC ₅₀ of 6.8 µM. Ac-CoA Synthase Inhibitor1 inhibits HepG2 utilization of [ ¹⁴ C]acetate for histone acetylation with IC ₅₀ of 5.5 µM ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 31.25 mg/mL ( 76.12 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4360 mL	12.1800 mL	24.3599 mL
5 mM	0.4872 mL	2.4360 mL	4.8720 mL
10 mM	0.2436 mL	1.2180 mL	2.4360 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.09 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution

* All of the co-solvents are available by MCE.