[CAS NO. 5092-09-1] Saikogenin A

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PRODUCTS SPECIFICATIONS [5092-09-1]

Catalog

HY-N6584

Brand

MCE

CAS

5092-09-1

DESCRIPTION [5092-09-1]

Overview

MDL	-
Molecular Weight	472.70
Molecular Formula	C30H48O4
SMILES	C[C@]12[C@]3(C(C=C[C@]1([H])[C@@]4([C@@]([C@@](C)([C@@H](O)CC4)CO)([H])CC2)C)=C5[C@](CO)(CCC(C)(C)C5)[C@@H](O)C3)C

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Phytother Res. 2020 Apr;34(4):788-795.

Summary

Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV ( DPP-IV ) inhibitor.

IC50 & Target

DPP-IV ^[1]

In Vitro

Saikogenin A has certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6%. DPP-IV is a non-classical serine aminopeptidase from its amino terminus of polypeptides and proteins (N-terminus) removing Xaa-Pro dipeptide ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Saikogenin A, an anti-inflammatory drug, is present in the crude extract of a Chinese herbal plant called Tsai-Fu. Saikogenin A is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema. The anti-inflammatory action of Saikogenin A are due to an increase in corticosterone caused by the release of arenocorticotropic hormone (ACTH) and a direct effect on the process of inflammation ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 52.89 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1155 mL	10.5775 mL	21.1551 mL
5 mM	0.4231 mL	2.1155 mL	4.2310 mL
10 mM	0.2116 mL	1.0578 mL	2.1155 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.29 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.29 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.29 mM); Clear solution

* All of the co-solvents are available by MCE.