[CAS NO. 5106-98-9] 4-Chlorosalicylic acid
PRODUCTS SPECIFICATIONS [5106-98-9]
DESCRIPTION [5106-98-9]
Overview
| MDL | MFCD00002449 |
|---|---|
| Molecular Weight | 172.56 |
| Molecular Formula | C7H5ClO3 |
| SMILES | C1=CC(=CC(=C1C(O)=O)O)Cl |
Summary
4-Chlorosalicylic acid is a pharmaceutical intermediate. Inhibits monophenolase and diphenolase activity with IC 50 s of 1.89 mM and 1.10 mM. Potent antimicrobial activity. Against E. coli with the MIC of 250 μg/mL and with the MBC of 500 μg/mL.
IC50 & Target
IC50: 1.89 mM (monophenolase), 1.10 mM (diphenolase) [1]
In Vitro
4-chlorosalicylic acid could inhibit both the diphenolase activity and the monophenolase activity of mushroom tyrosinase. 4-chlorosalicylic acid has broad-spectrum antimicrobial activity which could inhibits Gram-positive and Gram-negative bacteria and fungi [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 579.51 mM ; Need ultrasonic)
H 2 O : 1 mg/mL ( 5.80 mM ; ultrasonic and warming and heat to 80°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.7951 mL | 28.9754 mL | 57.9509 mL |
| 5 mM | 1.1590 mL | 5.7951 mL | 11.5902 mL |
| 10 mM | 0.5795 mL | 2.8975 mL | 5.7951 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (14.49 mM); Clear solution
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3.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (14.49 mM); Clear solution
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4.
Add each solvent one by one: PBS
Solubility: 2 mg/mL (11.59 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Synonyms