[CAS NO. 5154-02-9] 1,5-Isoquinolinediol

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PRODUCTS SPECIFICATIONS [5154-02-9]

Catalog

HY-W015422

Brand

MCE

CAS

5154-02-9

DESCRIPTION [5154-02-9]

Overview

MDL	MFCD00006900
Molecular Weight	161.16
Molecular Formula	C9H7NO2
SMILES	O=C1NC=CC2=C1C=CC=C2O

For research use only. We do not sell to patients.

Summary

1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC ₅₀ of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina ^[1] ^[2] .

IC50 & Target

PARP

0.18-0.37 μM (IC ₅₀ )

In Vitro

1,5-isoquinolinediol leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene ^[1] .
1,5-Isoquinolinediol is a potent PARP antagonist and decreases cleaved PARP in diabetic retina. 1,5-Isoquinolinediol (500 μM H2O2; 24 hours) attenuates H2O2-induced upregulation of cleaved PARP-1 expression in retinal Muller cells. 1,5-Isoquinolinediol attenuates diabetes-induced upregulation of retinal nitrated protein expression. 1,5-Isoquinolinediol attenuates diabetes-induced activation of NADPH oxidase in the retina ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 37.04 mg/mL ( 229.83 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.2050 mL	31.0251 mL	62.0501 mL
5 mM	1.2410 mL	6.2050 mL	12.4100 mL
10 mM	0.6205 mL	3.1025 mL	6.2050 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (12.91 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (12.91 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (12.91 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Crockett SL, et al. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatr Res. 2019 Dec 9.

Synonyms

1(2H)-Isoquinolinone, 5-hydroxy-

1,5-Isoquinolinediol

5-Hydroxy-1(2H)-isoquinolinone

1,5-Dihydroxyisoquinoline

NSC 65585

1,5-IQD