[CAS NO. 51543-39-6] (S)-Flurbiprofen

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PRODUCTS SPECIFICATIONS [51543-39-6]

Catalog

HY-15123

Brand

MCE

CAS

51543-39-6

DESCRIPTION [51543-39-6]

Overview

MDL	MFCD00866152
Molecular Weight	244.26
Molecular Formula	C15H13FO2
SMILES	O=C(O)[C@@H](C)C1=CC=C(C2=CC=CC=C2)C(F)=C1

For research use only. We do not sell to patients.

Summary

(S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC ₅₀ values of 0.48 μM and 0.47 μM for COX-1 and COX-2 , respectively ^[1] .

IC50 & Target

COX-1

0.48 μM (IC ₅₀ )

COX-2

0.47 μM (IC ₅₀ )

In Vitro

(S)-Flurbiprofen (10 ^–7 M) results in a total suppression of basal and stimulated PGE2 release in rat skin ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT03434197	Taisho Pharmaceutical Co., Ltd.	Osteoarthritis Knee Pain	February 5, 2018	Phase 3
NCT04908748	Teikoku Seiyaku Co., Ltd.\|Clinsearch GmbH\|CRM Biometrics GmbH\|Clinigen GmbH	Soft Tissue Injuries\|Contusions\|Strains\|Sprains\|Bruises	May 20, 2021	Phase 2
NCT02729207	Teikoku Seiyaku Co., Ltd.	Ankle Sprain	July 2016	Phase 2
NCT04505787	SocraTec R&D GmbH\|Teikoku Seiyaku Co., Ltd.\|SocraMetrics GmbH	Comparative Bioavailability	July 24, 2020	Phase 1

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 409.40 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0940 mL	20.4700 mL	40.9400 mL
5 mM	0.8188 mL	4.0940 mL	8.1880 mL
10 mM	0.4094 mL	2.0470 mL	4.0940 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (10.23 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (10.23 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

[1,1′-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, (αS)-

[1,1′-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, (S)-

(αS)-2-Fluoro-α-methyl[1,1′-biphenyl]-4-acetic acid

d-Flurbiprofen

(+)-Flurbiprofen

S-(+)-Flurbiprofen

(S)-Flurbiprofen

(+)-(S)-Flurbiprofen

Esflurbiprofen

(2S)-2-(2-Fluoro-1,1′-biphenyl-4-yl)propanoic acid

(2S)-2-(2-Fluoro-4-biphenyl)propanoic acid

Dexflurbiprofen

(S)-2-(2-Fluorobiphenyl-4-yl)propanoic acid

(S)-2-(2-Fluoro-[1,1′-biphenyl]-4-yl)propanoic acid

(2S)-2-(2-Fluoro-1,1′-biphenyl-4-yl)propanoic acid

(S)-2-(2-Fluoro-[1,1′-biphenyl]-4-yl)propanoicacid