[CAS NO. 520-27-4] Diosmin

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PRODUCTS SPECIFICATIONS [520-27-4]

Catalog

HY-N0178

Brand

MCE

CAS

520-27-4

DESCRIPTION [520-27-4]

Overview

MDL	MFCD00009772
Molecular Weight	608.54
Molecular Formula	C28H32O15
SMILES	O=C1C=C(C2=CC=C(OC)C(O)=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO[C@H]5[C@@H]([C@@H]([C@H]([C@H](C)O5)O)O)O)O4)O)O)O)=CC(O)=C13

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor ( AhR ).

IC50 & Target

AhR ^[1]

In Vitro

Treatment with Diosmin causes a dose dependent increase in the amount of adducts formed (up to a 7-fold increase in adducts at 5 μM Diosmin). At 5 μM, Diosmin increases the cytotoxicity of 7,12-dimethylbenz(a)anthracene (DMBA), shifting the IC ₅₀ of DMBA from an estimated 1.2 μM to 400 nM. Diosmin is not cytotoxic in itself at the concentrations tested. Diosmin causes an increase in CYPIAI activity in MCF-7 cells in a time- and dose-dependent fashion. Diosmin causes a dose-dependent increase in CYPIAI mRNA after 24 h of incubation, causes a long-lasting increase in CYPIAI mRNA accumu lation that reaches its peak after 48 h of incubation ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Diosmin significantly decreases the malondialdehyde (MDA) levels and increases the activities of total-superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in the retina of rats compare with the ischemia group (P<0.05), and suppresses the ischemia/reperfusion (I/R)-induced reduction in the a- and b-wave amplitudes of the electroretinograms (ERGs) (P<0.05). The thickness of the entire retina, inner nuclear layer, inner plexiform layer, and outer retinal layer and the number of cells in the ganglion cell layer are significantly less after I/R injury (P<0.05), and Diosmin remarkably ameliorates these changes on retinal morphology. Diosmin also attenuates the I/R-induced loss of retinal ganglion cells (RGCs) of the rat retina (P<0.05) ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT05626166	Tanta University	Ulcerative Colitis	November 2022	Phase 3
NCT02616731	Ain Shams University	Menorrhagia	September 2015	Phase 1\|Phase 2
NCT03413618	Pirogov Russian National Research Medical University	Deep Vein Thrombosis\|Postthrombotic Syndrome	December 20, 2017	Phase 4
NCT03471910	Fundação Educacional Serra dos Órgãos	Venous Insufficiency	June 20, 2017	Phase 4
NCT04358497	Hospital de Clínicas Dr. Manuel Quintela\|University of the Republic, Uruguay\|Centro Cardiovascular Universitario\|Centro Hospitalario Pereyra Rossell	Pelvic Congestive Syndrome\|Pelvic Varices\|Venous Disease	October 1, 2020	Phase 4
NCT01532882	Laboratoire Innotech International	Chronic Venous Disease of Lower Limbs	January 2012	Phase 3
NCT02927483	SunWave Pharma\|Opera CRO, a TIGERMED Group Company	Chronic Venous Insufficiency	November 2016	Phase 3
NCT02134249	Benha University	Infertility	April 2014	Phase 2\|Phase 3
NCT04933591	Pirogov Russian National Research Medical University	Varicose Veins	September 1, 2020	Not Applicable
NCT04452799	Tanta University	Coronavirus Infection	July 1, 2020	Early Phase 1

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 164.33 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6433 mL	8.2164 mL	16.4328 mL
5 mM	0.3287 mL	1.6433 mL	3.2866 mL
10 mM	0.1643 mL	0.8216 mL	1.6433 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (4.11 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: 2.5 mg/mL (4.11 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

Synonyms

4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-

Diosmin

7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

Diosmetin 7-β-rutinoside

3′,5,7-Trihydroxy-4′-methoxyflavone 7-O-rutinoside

Diosmine

Diosmetin 7-rutinoside

Venosmine

Diosmetin 7-O-rhamnosyl(1→6)-glucoside

Insuven

Diosmil

Diovenor

Ven-Detrex

Litosmil

Buchu resin

Hemerven

Flebosten

Barosmin

Varinon

Diosven

Flebosmil

Tovene

Dioven

Venex 500

3′,5-Dihydroxyl-4′-methoxylflavanone-7-O-α-L-rhamnosyl (1→6)-β-D-glucopyranoside

Diosmetin 7-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside

Diosmetin 7-O-rutinoside

Phlebodia

Flebodia