[CAS NO. 52806-53-8] Hydroxyflutamide

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PRODUCTS SPECIFICATIONS [52806-53-8]

Catalog

HY-W013272

Brand

MCE

CAS

52806-53-8

DESCRIPTION [52806-53-8]

Overview

MDL	MFCD00563126
Molecular Weight	292.21
Molecular Formula	C11H11F3N2O4
SMILES	CC(C)(O)C(NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1)=O

For research use only. We do not sell to patients.

Summary

Hydroxyflutamide (HF), an active metabolite of Flutamide, is a potent androgen receptor antagonist ( IC ₅₀ =700 nM). Hydroxyflutamide can be used for the research of prostate cancer ^[1] ^[2] .

IC50 & Target

IC50: 700 nM (androgen receptor) ^[1]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT02023398	BTL Industries Ltd.	Circumferential Reduction\|Waist Circumferential Reduction	September 2013	Not Applicable
NCT03244761	Capital Medical University	Tracheostomy	July 1, 2017
NCT04089410	I.M. Sechenov First Moscow State Medical University	Hypoxia, Altitude\|Exercise Tolerance\|Metabolic Disturbance\|Quality of Life	January 14, 2019	Not Applicable

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 342.22 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4222 mL	17.1110 mL	34.2220 mL
5 mM	0.6844 mL	3.4222 mL	6.8444 mL
10 mM	0.3422 mL	1.7111 mL	3.4222 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (8.56 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.56 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (8.56 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Propanamide, 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-

2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

α,α,α-Trifluoro-2-methyl-4′-nitro-m-lactotoluidide

Sch 16423

Hydroxyniphtholide

Hydroxyflutamide

2-Hydroxyflutamide