[CAS NO. 53005-05-3] DIDS
PRODUCTS SPECIFICATIONS [53005-05-3]
DESCRIPTION [53005-05-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 454.52 |
| Molecular Formula | C16H10N2O6S4 |
| SMILES | O=S(C1=CC(N=C=S)=CC=C1/C=C/C2=CC=C(C=C2S(=O)(O)=O)N=C=S)(O)=O |
Summary
In Vitro
DIDS (0-10 μM) inhibits RAD51-mediated strand exchange
[1]
.
DIDS (0-20 μM) inhibits DNA binding by RAD51
[1]
.
DIDS (10 μM; 0-60 min) stimulates the ATP hydrolyzing activity of RAD51 in the absence of DNA
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Ishida T, et, al. DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange. Nucleic Acids Res. 2009 Jun;37(10):3367-76.
- [2] Lepke S, et, al. A study of the relationship between inhibition of anion exchange and binding to the red blood cell membrane of 4,4'-diisothiocyano stilbene-2,2'-disulfonic acid (DIDS) and its dihydro derivative (H2DIDS). J Membr Biol. 1976 Oct 20;29(1-2):147-77.