[CAS NO. 5302-45-4] Dencichine
PRODUCTS SPECIFICATIONS [5302-45-4]
DESCRIPTION [5302-45-4]
Overview
| MDL | MFCD00055228 |
|---|---|
| Molecular Weight | 176.13 |
| Molecular Formula | C5H8N2O5 |
| SMILES | N[C@@H](CNC(C(O)=O)=O)C(O)=O |
Summary
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng , and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.
IC50 & Target
PHD-2 [1]
In Vitro
Dencichin (β-ODAP, 10 μM, 50 μM, 100 μM and 200 μM) increases HRE expression by 1.3±0.09, 2.5±0.07, 4.2±0.15 and 1.3±0.07 fold respectively compared to control. Dencichin has intermolecular interactions with PHD-2 [1] . Dencichin (10 μM, 100 μM, 1 mM) significantly inhibits cell proliferation and extracellular matrix (ECM) proteins accumulation of HBZY-1 cells, and reduces the secretion of collagen I (Col I), collagen IV (Col IV), and fibronectin (FN) [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Dencichin improves metabolism disorder in diabetic nephropathy (DN) secondary to type II diabetes mellitus (DM) model. Dencichin (80, 160 mg/kg/day, p.o.) significantly prevents the up-regulation of TCH, TG, LDL, and HbAlc and the down-regulation of HDL in DN rats induced by STZ injection. Dencichin also attenuates renal injury induced in the DN secondary to type II DM model. Dencichin alleviates pancreas damage in the STZ-induced DN model. Dencichin regulates protein expression in the TGF-β/Smad signalling pathway in STZ-induced DN models [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 5 mg/mL ( 28.39 mM ; Need ultrasonic)
H 2 O : 5 mg/mL ( 28.39 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.6776 mL | 28.3881 mL | 56.7762 mL |
| 5 mM | 1.1355 mL | 5.6776 mL | 11.3552 mL |
| 10 mM | 0.5678 mL | 2.8388 mL | 5.6776 mL |
References
- [1] Eslavath RK, et al. β-N-oxalyl-L-α, β- diaminopropionic acid induces HRE expression by inhibiting HIF-prolyl hydroxylase-2 in normoxic conditions. Eur J Pharmacol. 2016 Nov 15;791:405-411.
- [2] Jie L, et al. Dencichine ameliorates kidney injury in induced type II diabetic nephropathy via the TGF-β/Smad signalling pathway. Eur J Pharmacol. 2017 Oct 5;812:196-205.
Synonyms