[CAS NO. 53716-49-7] Carprofen
PRODUCTS SPECIFICATIONS [53716-49-7]
DESCRIPTION [53716-49-7]
Overview
| MDL | MFCD00079028 |
|---|---|
| Molecular Weight | 273.71 |
| Molecular Formula | C15H12ClNO2 |
| SMILES | O=C(O)C(C)C1=CC(NC2=C3C=C(Cl)C=C2)=C3C=C1 |
2 Publications Citing Use of MCE
Summary
IC50 & Target
|
COX-2 3.9 μM (IC 50 ) |
COX-1 22.3 μM (IC 50 ) |
FAAH 78.6 μM (IC 50 ) |
In Vitro
Carprofen (Compound 1) is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC
50
s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively
[1]
.
Carprofen (10 µg/mL) shows cytoprotective effects in CCL and CaCL cells and decreases apoptosis of both cells. Carprofen (10 µg/mL) exhibits nonsignificant increase in PGE2 concentration, compared with that of the respective CCL or CaCL controls
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Carprofen (2.2 mg/kg, p.o.) significantly decreases PGE2 concentration in blood of dogs on days 3 and 10. Carprofen also decreases amounts of gastric PGE2 synthesis on day 3, but the inhibition is not obvious on day 10. In addition, Carprofen shows no activity against gastric PGE1 synthesis in dogs on day 3 and 10 [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 365.35 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.6535 mL | 18.2675 mL | 36.5350 mL |
| 5 mM | 0.7307 mL | 3.6535 mL | 7.3070 mL |
| 10 mM | 0.3654 mL | 1.8268 mL | 3.6535 mL |
References
- [1] Favia AD, et al. Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor. J Med Chem. 2012 Oct 25;55(20):8807-26.
- [2] Waldherr K, et al. In vitro cytoprotective effects of acetylsalicylic acid, carprofen, meloxicam, or robenacoxib against apoptosis induced by sodium nitroprusside in canine cruciate ligament cells. Am J Vet Res. 2012 Nov;73(11):1752-8.
- [3] Sessions JK, et al. In vivo effects of carprofen, deracoxib, and etodolac on prostanoid production in blood, gastric mucosa, and synovial fluid in dogs with chronic osteoarthritis. Am J Vet Res. 2005 May;66(5):812-7.
Synonyms