[CAS NO. 543700-68-1] BMS-433771

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PRODUCTS SPECIFICATIONS [543700-68-1]

Catalog

HY-120632

Brand

MCE

CAS

543700-68-1

DESCRIPTION [543700-68-1]

Overview

MDL	-
Molecular Weight	377.44
Molecular Formula	C21H23N5O2
SMILES	O=C(N(C1=C2C=CN=C1)CC3=NC4=CC=CC=C4N3CCCCO)N2C5CC5

For research use only. We do not sell to patients.

Summary

BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV) . BMS-433771 is active against both A and B groups of RSV , with an average EC ₅₀ of 20 nM. BMS-433771 can be used for the research of respiratory tract disease ^[1] ^[2] .

IC50 & Target

EC50: 20 nM (RSV) ^[1]

In Vitro

BMS-433771 has inhibitory against both A and B groups of RSV, with an average EC ₅₀ of 20 nM ^[1] .
BMS-433771 can inhibit viral F protein-induced membrane fusion ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BMS-433771 (p.o.; 1-200 mg/kg; single or bid 4 days) shows prophylactic efficacy via oral dosing，but has considerable pharmacodynamic differences between the two rodent models ^[2]
.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	rodent models of RSV infection ^[2] (cotton rat and mice)
Dosage:	1, 10, and 50 mg/kg (mice); 25, 50, 100, and 200 mg/kg (rat)
Administration:	oral, single or bid 4 days
Result:	Had prophylactic efficacy via oral dosing in both animal models. Showed RSV infection more sensitive to inhibition in the BALB/c mouse host than in the cotton rat.

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Please store the product under the recommended conditions in the Certificate of Analysis.