[CAS NO. 5466-89-7] U-0521
PRODUCTS SPECIFICATIONS [5466-89-7]
DESCRIPTION [5466-89-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 180.20 |
| Molecular Formula | C10H12O3 |
| SMILES | CC(C(C1=CC=C(C(O)=C1)O)=O)C |
Summary
IC50 & Target
COMT [1]
In Vitro
U-0521 inhibits RBC COMT activity in a dose-dependent manner with an IC 50 of 6 x10 -6 M [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
U-0521 (i.p.; 0-250 mg/kg; 10 min) inhibits COMT activity in a dose-dependent manner. 50% inhibition of enzyme activity is obtained at 90 mg/kg and maximum inhibition of 90% is obtained at 250 mg/kg [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male Sprague-Dawley rats (180-250 g) [1] |
| Dosage: | 0-250 mg/kg |
| Administration: | i.p.; 10 min |
| Result: | Inhibited COMT activity in a dose-dependent manner. 50% inhibition of enzyme activity was obtained at 90mg/kg and maximum inhibition of 90% was obtained at 250 mg/kg. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 554.94 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.5494 mL | 27.7469 mL | 55.4939 mL |
| 5 mM | 1.1099 mL | 5.5494 mL | 11.0988 mL |
| 10 mM | 0.5549 mL | 2.7747 mL | 5.5494 mL |
Synonyms