[CAS NO. 55-18-5]  N-Nitrosodiethylamine

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PRODUCTS SPECIFICATIONS [55-18-5]

Catalog
HY-N7434
Brand
MCE
CAS
55-18-5

DESCRIPTION [55-18-5]

Overview

MDL-
Molecular Weight102.14
Molecular FormulaC4H10N2O
SMILESCCN(CC)N=O

For research use only. We do not sell to patients.

Summary

N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication . N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.


Appearance

Liquid



Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)


Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 979.05 mM ; Need ultrasonic)

H 2 O : 100 mg/mL ( 979.05 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.7905 mL 48.9524 mL 97.9048 mL
5 mM 1.9581 mL 9.7905 mL 19.5810 mL
10 mM 0.9790 mL 4.8952 mL 9.7905 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: PBS

    Solubility: 100 mg/mL (979.05 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

  • 2.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (24.48 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (24.48 mM); Clear solution

  • 4.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (24.48 mM); Clear solution

* All of the co-solvents are available by MCE.

Synonyms

Ethanamine, N-ethyl-N-nitroso-
Diethylamine, N-nitroso-
N-Ethyl-N-nitrosoethanamine
DENA
Diethylnitrosamine
Diethylnitrosoamine
Nitrosodiethylamine
N-Nitrosodiethylamine
Diethylnitrosamide
N,N-Diethylnitrosoamine
N-Nitroso-N,N-diethylamine
DEN
DEN (mutagen)
NDEA
NSC 132