[CAS NO. 553-08-2] Thonzonium bromide

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PRODUCTS SPECIFICATIONS [553-08-2]

Catalog

HY-B1246

Brand

MCE

CAS

553-08-2

DESCRIPTION [553-08-2]

Overview

MDL	MFCD00133855
Molecular Weight	591.71
Molecular Formula	C32H55BrN4O
SMILES	CCCCCCCCCCCCCCCC[N+](C)(CCN(CC1=CC=C(OC)C=C1)C2=NC=CC=N2)C.[Br-]

For research use only. We do not sell to patients.

5 Publications Citing Use of MCE

Summary

Thonzonium bromide is an antibacterial agent that is structurally similar to Farnesol (HY-Y0248A). Thonzonium bromide is also a monocationic surface-active agent, which inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Thonzonium bromide inhibits proton transport in a dose-dependent manner (EC ₅₀ =69 μM) ^[1] ^[2] ^[3] .

In Vitro

Thonzonium bromide inhibits RANKL-induced OC formation, the appearance of OC-specific marker genes and bone-resorbing activity in vitro. Thonzonium bromide blocks the RANKL-induced activation of NF-κB, ERK and c-Fos as well as the induction of NFATc1 which is essential for OC formation. Thonzonium bromide disrupts F-actin ring formation resulting in disturbances in cytoskeletal structure in mature OCs during bone resorption. Thonzonium bromide exhibits protective effects in an in vivo murine model of LPS-induced calvarial osteolysis ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

H ₂ O : 100 mg/mL ( 169.00 mM ; Need ultrasonic)

DMSO : ≥ 30 mg/mL ( 50.70 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6900 mL	8.4501 mL	16.9002 mL
5 mM	0.3380 mL	1.6900 mL	3.3800 mL
10 mM	0.1690 mL	0.8450 mL	1.6900 mL

* Please refer to the solubility information to select the appropriate solvent.

References

Synonyms

1-Hexadecanaminium, N-[2-[[(4-methoxyphenyl)methyl]-2-pyrimidinylamino]ethyl]-N,N-dimethyl-, bromide (1:1)

Ammonium, hexadecyl[2-[(p-methoxybenzyl)-2-pyrimidinylamino]ethyl]dimethyl-, bromide

Hexadecyl[2-[(p-methoxybenzyl)-2-pyrimidinylamino]ethyl]dimethylammonium bromide

1-Hexadecanaminium, N-[2-[[(4-methoxyphenyl)methyl]-2-pyrimidinylamino]ethyl]-N,N-dimethyl-, bromide

NC 1264

Cetyl[2-[(p-methoxybenzyl)-2-pyrimidinylamino]ethyl]dimethylammonium bromide

N-(2-Pyrimidyl)-N-(p-methoxybenzyl)-N′,N′-dimethyl-N′-cetyl-N′-bromoethylenediamine

Thonzide

Thonzonium bromide

Tonzonium bromide