[CAS NO. 554438-52-7] LASV inhibitor 3.3
PRODUCTS SPECIFICATIONS [554438-52-7]
DESCRIPTION [554438-52-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 471.63 |
| Molecular Formula | C30H37N3O2 |
| SMILES | O=C(C1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1)NCC(N(CC4)CCN4C(C5=CC=CC=C5)C6=CC=CC=C6)=O |
Summary
LASV inhibitor 3.3 is a Lassa fever virus ( LASV ) inhibitor. LASV inhibitor 3.3 binds with LASV glycoprotein (GP) and promotes virus membrane fusion and infection . LASV inhibitor 3.3 can be used for LASV infection research [1] .
In Vitro
LASV inhibitor 3.3 (1 nM-100 μM; 1 h) inhibits transduction by murine leukemia virus (MLV) pseudotyped with the indicated viral glycoproteins with an IC
50
value of 1.8 μM
[1]
.
LASV inhibitor 3.3 (1 and 10 μM; 1 h) inhibits LAMP1 binding to LASV GP in vitro
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | 293T LAMP1 KO cells expressing LASV GP-His and 293T pX459 cells |
| Concentration: | 1 and 10 μM |
| Incubation Time: | 1 hour |
| Result: | Inhibited the LASV GP binds to LAMP1. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |