[CAS NO. 55497-79-5] Myriceric acid B
PRODUCTS SPECIFICATIONS [55497-79-5]
DESCRIPTION [55497-79-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 634.84 |
| Molecular Formula | C39H54O7 |
| SMILES | OC1=C(O)C=CC(/C=C/C(OC[C@]23[C@@]4(C)[C@@](CC=C2[C@@]5([H])[C@](C(O)=O)(CCC(C)(C)C5)CC3)([H])[C@@]6([C@@](C(C)([C@@H](O)CC6)C)([H])CC4)C)=O)=C1 |
Summary
IC50 & Target
|
HIV-1 8.3±0.2 μg/mL (IC 50 , infection of HIV-1 Env pseudovirus) |
In Vitro
Myriceric acid B (0-30 μM; 72 h) shows potent cytotoxicity against tumor cells
[1]
.
Myriceric acid B significantly inhibits the infection of HIV-1 Env pseudovirus with an IC
50
of 8.3±0.2 mg/L
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Cytotoxicity Assay [1]
| Cell Line: | A549, SK-OV-3, SK-MEL-2 and Bt549 |
| Concentration: | 0-30 μM |
| Incubation Time: | 72 h |
| Result: | Exhibited potent cytotoxicity against all of the tumor cell lines tested, with IC 50 s of 5.7±0.3, 9.8±0.5, 6.0±0.7 and 5.8±0.4 μM against A549, SK-OV-3, SK-MEL-2 and Bt549, respectively. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Eom HJ, et al. Cytotoxic Triterpenoids from the Barks of Betula platyphylla var. japonica. Chem Biodivers. 2017 Apr;14(4).
- [2] Xia C, et al. The anti-HIV-1 entrance activity and mechanism of action of myriceric acid B from Rhoiptelea chiliantha Diels et Hand-Mazz. Chinese Pharmacological Bulletin, 2010: 447-452.