[CAS NO. 566203-88-1] AZD2098

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PRODUCTS SPECIFICATIONS [566203-88-1]

Catalog

HY-U00064

Brand

MCE

CAS

566203-88-1

DESCRIPTION [566203-88-1]

Overview

MDL	MFCD31382158
Molecular Weight	334.18
Molecular Formula	C11H9Cl2N3O3S
SMILES	O=S(C1=CC=CC(Cl)=C1Cl)(NC2=NC=CN=C2OC)=O

For research use only. We do not sell to patients.

3 Publications Citing Use of MCE

Summary

AZD2098 is a potent and selective CC-chemokine receptor 4 (CCR4) inhibitor with pIC ₅₀ s of 7.8, 8.0, 8.0 and 7.6 for human, rat, mouse and dog respectively, used for asthma research ^[1] ^[2] .

IC50 & Target

CCR4

In Vitro

AZD2098 potently inhibits chemokine-induced cellular responses, with pIC ₅₀ of 7.5 and 6.3 against CCL22-induced Ca ²⁺ influx in hCCR4-expressing CHO cells and CCL17- or CCL22-induced chemotaxis of primary human Th2 cells respectively ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AZD2098 (73.5-5.0 μg/kg; p.o.; BID; twice a day; 1 hour before and every 12 hours after antigen challenge) exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats, and the changes are first visible at a dose of 0.22 µmol/kg and maximal at 7.5 µmol/kg ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Brown-Norway rats ^[1]
Dosage:	73.5 µg/kg, 250.6 µg/kg, 735.2 µg/kg, 1.0 mg/kg, 2.5 mg/kg, 5.0 mg/kg
Administration:	Oral administration; twice a day; 1 hour before and every 12 hours after antigen challenge
Result:	Exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 299.24 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9924 mL	14.9620 mL	29.9240 mL
5 mM	0.5985 mL	2.9924 mL	5.9848 mL
10 mM	0.2992 mL	1.4962 mL	2.9924 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (7.48 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.48 mM); Clear solution

* All of the co-solvents are available by MCE.