[CAS NO. 56741-95-8] Bropirimine

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PRODUCTS SPECIFICATIONS [56741-95-8]

Catalog

HY-W008634

Brand

MCE

CAS

56741-95-8

DESCRIPTION [56741-95-8]

Overview

MDL	MFCD00813905
Molecular Weight	266.09
Molecular Formula	C10H8BrN3O
SMILES	O=C1NC(N)=NC(C2=CC=CC=C2)=C1Br

For research use only. We do not sell to patients.

Summary

Bropirimine is a synthetic agonist for toll-like receptor 7 (TLR7) . Bropirimine inhibits differentiation of osteoclast precursor cells into osteoclasts via TLR7-mediated production of IFN-β. Bropirimine is an orally active immunomodulator that has demonstrated anticancer activity in transitional cell carcinoma in situ (CIS) in both the bladder and upper urinary tract ^[1] ^[2] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 187.91 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7581 mL	18.7906 mL	37.5813 mL
5 mM	0.7516 mL	3.7581 mL	7.5163 mL
10 mM	0.3758 mL	1.8791 mL	3.7581 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (7.82 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (7.82 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (7.82 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

4(3H)-Pyrimidinone, 2-amino-5-bromo-6-phenyl-

4(1H)-Pyrimidinone, 2-amino-5-bromo-6-phenyl-

2-Amino-5-bromo-6-phenyl-4(3H)-pyrimidinone

5-Bromo-6-phenylisocytosine

2-Amino-5-bromo-6-phenyl-4-pyrimidinol

NSC 149027

2-Amino-5-bromo-6-phenyl-4-pyrimidinone

5-Bromo-2,3-dihydro-2-imino-6-phenyl-4(1H)-pyrimidinone

Bropirimine

U 54461

U 54461S

PNU 54461

2-Amino-5-bromo-4-hydroxy-6-phenylpyrimidine

2-Amino-5-bromo-6-phenyl-1H-pyrimidin-4-one

2-Amino-5-bromo-6-phenyl-3,4-dihydropyrimidin-4-one