[CAS NO. 568-73-0] Tanshinone I
PRODUCTS SPECIFICATIONS [568-73-0]
DESCRIPTION [568-73-0]
Overview
| MDL | MFCD00210563 |
|---|---|
| Molecular Weight | 276.29 |
| Molecular Formula | C18H12O3 |
| SMILES | O=C(C1=C2C=CC3=C1C=CC=C3C)C(C4=C2OC=C4C)=O |
1 Publications Citing Use of MCE
Summary
Tanshinone I is an inhibitor of type IIA human recombinant sPLA 2 ( IC 50 =11 μM) and rabbit recombinant cPLA 2 ( IC 50 =82 μM).
IC50 & Target
IC50: 11 μM (sPLA 2 ), 82 μM (cPLA 2 ) [1] .
In Vitro
Tanshinone I inhibits PGE 2 formation from LPS-induced RAW macrophages (IC 50 =38 μM). When Tanshinone I is added simultaneously with LPS, this compound clearly inhibits PGE2 production (IC 50 =38 μM) at 10-100 μM. Tanshinone I also reduces PGE2 production (IC 50 =46 μM) when added after COX-2 is fully induced. The fact that Tanshinone I inhibits PGE2 production by pre-induced COX-2 strongly suggests that this compound may directly inhibit COX-2 activity and/or affect PLA 2 activity. When Tanshinone I is incubated with two different forms of phospholipase A 2 (PLA 2 ), it clearly inhibits sPLA 2 (IC 50 =11 μM) in a concentration-dependent manner. Although being less potent, Tanshinone I also inhibits cPLA 2 (IC 50 =82 μM) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Tanshinone I shows antiinflammatory activity in rat carrageenan-induced paw oedema and adjuvant-induced arthritis. In order to establish the anti-inflammatory activity of Tanshinone I, the classical animal models of acute and chronic inflammation [rat carrageenan (CGN)-induced paw oedema and rat adjuvant-induced arthritis (AIA)] are employed. When Tanshinone I is orally administered, it shows significant anti-inflammatory activity against CGN-induced paw oedema (47% inhibition at 160 mg/kg), while the IC 50 of indomethacin is 7.1 mg/kg. In AIA, Tanshinone I gives 27% inhibition of secondary inflammation at 18 day with an oral dose of 50 mg/kg/day, whereas prednisolone (5 mg/kg/day) shows potent inhibition (65%) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 2 mg/mL ( 7.24 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.6194 mL | 18.0969 mL | 36.1939 mL |
| 5 mM | 0.7239 mL | 3.6194 mL | 7.2388 mL |
| 10 mM | --- | --- | --- |
Synonyms