[CAS NO. 568-80-9] Galloflavin
PRODUCTS SPECIFICATIONS [568-80-9]
DESCRIPTION [568-80-9]
Overview
| MDL | MFCD26941292 |
|---|---|
| Molecular Weight | 278.17 |
| Molecular Formula | C12H6O8 |
| SMILES | O=C(OC(C=C1O)=C2OC1=O)C3=C2C(O)=C(O)C(O)=C3 |
Summary
Galloflavin is a potent lactate dehydrogenase (LDH) inhibitor. The calculated K i s for pyruvate are 5.46 µM (LDH-A) and 15.06 µM (LDH-B). Galloflavin hinders the proliferation of cancer cells by blocking glycolysis and ATP production [1] [2] .
In Vitro
Galloflavin effectively inhibits cell growth in endometrial cancer cell lines and primary cultures of human endometrial cancer through its involvement in multiple signaling pathways that regulate metabolism, cell cycle, apoptosis, cell stress and metastasis [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 8.33 mg/mL ( 29.95 mM ; ultrasonic and warming and heat to 80°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.5949 mL | 17.9746 mL | 35.9492 mL |
| 5 mM | 0.7190 mL | 3.5949 mL | 7.1898 mL |
| 10 mM | 0.3595 mL | 1.7975 mL | 3.5949 mL |
References
- [1] Manerba M, Vettraino M, Fiume L, et al. Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase. ChemMedChem. 2012;7(2):311-317.
- [2] Farabegoli F, et al. Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways. Eur J Pharm Sci. 2012;47(4):729-738.
- [3] Han X, et al. Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells. J Hematol Oncol. 2015;8:2. Published 2015 Jan 29.