[CAS NO. 56839-43-1] Eperisone hydrochloride
PRODUCTS SPECIFICATIONS [56839-43-1]
DESCRIPTION [56839-43-1]
Overview
| MDL | MFCD00941459 |
|---|---|
| Molecular Weight | 295.85 |
| Molecular Formula | C17H26ClNO |
| SMILES | O=C(C1=CC=C(CC)C=C1)C(C)CN2CCCCC2.[H]Cl |
Summary
Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is an antispastic agent used for treatment of diseases characterized by muscle stiffness and pain. It works by relaxing both skeletal muscles and vascularsmooth muscles, thus demonstrating avariety of effects such as reduction ofmyotonia, improvement of circulationand suppression of the pain reflex. Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is a centrally acting muscle relaxant inhibiting the pain reflex pathway, having a vasodilator effect [1] [2 [3] .
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT00327730 | Eisai Inc.|Eisai Co., Ltd. |
Muscle Spasm; Back Pain
|
April 2006 | Phase 3 |
| NCT02289274 | NVP Healthcare |
Healthy
|
November 2019 | Phase 1 |
| NCT01300312 | Eisai Co., Ltd.|Eisai Inc. |
Acute Musculoskeletal Spasm Due to Low Back Pain
|
February 2011 | Phase 3 |
| NCT01306318 | Eisai Co., Ltd.|Eisai Inc. |
Healthy Volunteers
|
February 2011 | Not Applicable |
| NCT03337607 | First Affiliated Hospital of Zhejiang University|Ludwig-Maximilians - University of Munich |
Low Back Pain
|
November 13, 2017 | Not Applicable |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 100 mg/mL ( 338.01 mM ; Need ultrasonic)
DMSO : 31.25 mg/mL ( 105.63 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3801 mL | 16.9005 mL | 33.8009 mL |
| 5 mM | 0.6760 mL | 3.3801 mL | 6.7602 mL |
| 10 mM | 0.3380 mL | 1.6900 mL | 3.3801 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 16.67 mg/mL (56.35 mM); Clear solution; Need ultrasonic
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (7.03 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (7.03 mM); Clear solution
References
- [1] Cabitza P, et al. Efficacy and safety of eperisone in patients with low back pain: a double blind randomized study. Eur Rev Med Pharmacol Sci. 2008 Jul-Aug;12(4):229-35.
- [2] Frandisco Colomer Rusinvol, et al. Effects of Two Diffferent Doses of Eperisone in the Treatment of Acute Low Back Pain. The Journal of Applied Research.
- [3] Bavage S, et al. Clinical efficacy and safety of eperisone for low back pain: A systematic literature review. Pharmacol Rep. 2016 Oct;68(5):903-12.
- [4] Park KH, Lee SC, Yuk JE, Kim SR, Lee JH, Park JW. Eperisone-Induced Anaphylaxis: Pharmacovigilance Data and Results of Allergy Testing. Allergy Asthma Immunol Res. 2019;11(2):231-240.
Synonyms