[CAS NO. 57-00-1] Creatine

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [57-00-1]

Catalog

HY-W010388

Brand

MCE

CAS

57-00-1

DESCRIPTION [57-00-1]

Overview

MDL	MFCD00004282
Molecular Weight	131.14
Molecular Formula	C4H9N3O2
SMILES	O=C(O)CN(C)C(N)=N

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Toxicol Appl Pharmacol. 9 March 2022, 115971.

Summary

Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.

IC50 & Target

Microbial Metabolite

Human Endogenous Metabolite

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT01175616	University of Utah	Major Depressive Disorder	September 2012	Phase 4
NCT00313417	Herzog Hospital\|Beersheva Mental Health Center	Major Depressive Disorder	January 2007	Phase 4
NCT04290819	University of Regina	Performance Enhancing Product Use	February 15, 2019	Not Applicable
NCT02047864	University of Saskatchewan	Osteoporosis\|Sarcopenia	January 2014	Not Applicable
NCT01163370	University of Sao Paulo	Osteopenia\|Osteoporosis	July 2010	Not Applicable
NCT03006861	University of Saskatchewan\|University of Guelph\|University of Prince Edward Island	Muscle Weakness	December 2016	Not Applicable
NCT00355576	Columbia University\|ALS Association\|Pfizer	Amyotrophic Lateral Sclerosis	July 2006	Phase 2
NCT03194334	University Ghent	Dietary Modification	December 2012	Not Applicable
NCT00069186	The Avicena Group	Amyotrophic Lateral Sclerosis (ALS)	June 2003	Phase 3
NCT02062086	University Hospital, Toulouse	Sarcopenia	June 2014	Not Applicable
NCT01655030	University of Sao Paulo	Bipolar I Disorder\|Current Episode Depressed	July 2012	Not Applicable
NCT01894737	Maastricht University Medical Center	Muscle Loss	October 2013	Not Applicable
NCT03987217	University of Utah\|National Cancer Institute (NCI)	Fatigue\|Metastatic Prostate Carcinoma\|Sedentary Lifestyle\|Stage IV Prostate Cancer AJCC (American Joint Committee on Cancer) v8\|Stage IVA Prostate Cancer AJCC (American Joint Committee on Cancer) v8\|Stage IVB Prostate Cancer AJCC (American Joint Committee on Cancer) v8	June 17, 2019	Early Phase 1
NCT00005674	National Center for Research Resources (NCRR)\|Muscular Dystrophy Association	Amyotrophic Lateral Sclerosis		Phase 2
NCT03003988	Texas A&M University\|Nutrabolt	Dietary Supplementation	September 2014	Not Applicable
NCT03350282	University of Novi Sad, Faculty of Sport and Physical Education	Energy Metabolism	December 1, 2016	Not Applicable
NCT00018109	National Center for Research Resources (NCRR)\|Children´s National Research Institute	Muscular Dystrophy, Duchenne		Phase 3
NCT00026988	National Center for Complementary and Integrative Health (NCCIH)	Huntington´s Disease	October 2001	Phase 1\|Phase 2
NCT04734626	Children´s Hospital of Philadelphia	Mitochondrial Diseases	May 25, 2021
NCT05201651	University of Regina	Young Healthy Adults (no Medical Condition+Disease)	February 10, 2022	Early Phase 1
NCT02356107	Perry Renshaw\|University of Utah	Major Depressive Disorder	April 2015	Phase 4
NCT04498078	University of Novi Sad, Faculty of Sport and Physical Education	Autism Spectrum Disorder	January 15, 2022	Not Applicable
NCT02370212	University of British Columbia	Healthy	March 2015	Not Applicable
NCT02463305	University of Colorado, Denver	Colitis, Ulcerative	August 2022	Early Phase 1
NCT00348933	University of California, San Diego\|Baylor College of Medicine\|Rady Children´s Hospital, San Diego\|Boston Children´s Hospital\|Greenwood Genetic Center\|Rare Diseases Clinical Research Network	Angelman Syndrome\|Nervous System Diseases	July 2006	Not Applicable
NCT04665804	Foundation University Islamabad	Knee Osteoarthritis	June 10, 2020	Not Applicable
NCT00729755	Ewha Womans University	Major Depressive Disorder	August 2008	Not Applicable
NCT02948244	Murdoch Childrens Research Institute	Facio-Scapulo-Humeral Dystrophy\|FSHD2\|FSHD1	October 31, 2017	Not Applicable
NCT03941678	University of Saskatchewan\|University of Regina	Stroke	May 30, 2019	Not Applicable
NCT03530202	University of Regina	Sarcopenia	January 1, 2018	Phase 2
NCT05562232	Psychiatric Research Unit, Region Zealand, Denmark\|University of Southern Denmark	Mild Traumatic Brain Injury\|Concussion, Brain	October 1, 2022	Not Applicable
NCT01472393	University of Sao Paulo\|AlzChem AG	Postmenopausal Women	November 2011	Not Applicable
NCT01164020	University of Sao Paulo	Cognition\|Aging	August 2010	Not Applicable
NCT01367717	Beth Israel Medical Center	Acute Kidney Injury	May 2009	Not Applicable
NCT03678857	Brandon University	Healthy	September 15, 2018	Not Applicable
NCT05451498	Rocky Mountain University of Health Professions\|Lindenwood University\|Mayo Clinic\|Western Michigan University	Healthy	February 9, 2022	Not Applicable
NCT05109039	University of Idaho	Creatine	September 27, 2021	Not Applicable
NCT02290275	University of Manitoba	Osteoarthritis, Knee	January 2015	Not Applicable
NCT03039829	Texas A&M University\|Nutrabolt	Nutritional Supplements	January 2016	Not Applicable
NCT00851006	University of Utah\|AlzChem, LLC	Major Depressive Disorder	April 2009	Phase 2
NCT00749983	University of Sao Paulo	Knee Osteoarthritis\|Fibromyalgia	June 2009	Not Applicable
NCT05272969	LMU Klinikum	Pompe Disease (Late-onset)\|Inclusion Body Myositis\|Spinal Muscular Atrophy Type 3\|FSHD	March 31, 2022
NCT00484627	National Center for Complementary and Integrative Health (NCCIH)	HIV Infections	August 2001	Phase 2
NCT00592995	Massachusetts General Hospital	Huntington Disease	December 2007	Phase 2
NCT04471792	Florida State University	Peripheral Arterial Disease	May 12, 2020	Phase 2
NCT01213719	University of Sao Paulo	Healthy Subjects	October 2010	Not Applicable
NCT02374112	Center for Health, Exercise and Sport Sciences, Serbia	Chronic Fatigue Syndrome	January 2016	Not Applicable
NCT00992043	University of Sao Paulo	Diabetes\|Renal Function	October 2009	Not Applicable
NCT04298840	Texas Tech University\|Legion Athletics, Inc	Dihydrotestosterone\|Testosterone\|Hair Loss	April 2020	Not Applicable
NCT04504253	University of Utah	Major Depressive Disorder	August 3, 2020	Phase 3
NCT03433651	Mike O´Callaghan Military Hospital	Depression	January 1, 2019	Phase 4
NCT01057680	University of Saskatchewan	Osteoporosis\|Sarcopenia	January 2010	Phase 3
NCT02188849	University of Chile	Muscle Weakness	October 2014	Phase 3
NCT02094781	GlaxoSmithKline	Nutritional Status	December 2013	Phase 1
NCT01725503	The Cleveland Clinic	Creatine Synthesis in Healthy Subjects	January 2010	Not Applicable
NCT01381354	University of Iowa\|Direct MS Canada\|DJO Incorporated\|Pinnaclife Inc.\|TZ Press, LLC	Multiple Sclerosis	October 2010	Phase 1
NCT01803230	University of Sao Paulo	Healthy	February 2013	Not Applicable
NCT00551434	Boston University	Coronary Artery Disease	August 2002	Not Applicable
NCT00797407	The Cleveland Clinic	Hypercholesterolemia\|Aches\|Cramps\|Weakness	August 2006	Not Applicable
NCT02993874	State University of Maringá\|Fundação de Amparo à Pesquisa do Estado do Amazonas	Intermittent Claudication	June 26, 2017	Not Applicable
NCT05148208	University Medical Center Groningen	Dialysis; Complications	January 1, 2022	Not Applicable
NCT01147575	Medical University of Vienna	Rett Syndrome	January 2005	Not Applicable
NCT00140192	Beersheva Mental Health Center\|National Alliance for Research on Schizophrenia and Depression	Schizophrenia	September 2004	Phase 3
NCT02134808	Perry Renshaw\|University of Utah	Major Depressive Disorder	November 21, 2014	Phase 4
NCT02099357	Universidade do Porto	Spinal Cord Injuries	September 2014	Not Applicable
NCT04007731	Zala Jenko Praznikar\|University of Primorska	Muscle Mass\|Inflammation\|Regeneration Muscle	July 1, 2019	Not Applicable
NCT01217320	University of Sao Paulo	Juvenile Systemic Lupus Erythematosus\|Juvenile Dermatomyositis	January 2011	Not Applicable
NCT01601210	Perry Renshaw\|University of Utah	Major Depressive Disorder	June 2012	Early Phase 1
NCT05329480	Radford University	Cardiac Function and Hemodynamics	February 9, 2022	Not Applicable
NCT03062683	RWTH Aachen University	Syncope\|Lactate Blood Increase	January 1, 2017
NCT05383833	University of Kansas Medical Center\|Alzheimer´s Association	Alzheimer´s Disease	November 30, 2022	Not Applicable
NCT01502813	Deborah Yurgelun-Todd\|University of Utah	Cognitive Benefits	February 1, 2012	Not Applicable
NCT04423887	Foundation University Islamabad	Knee Osteoarthritis	June 10, 2020	Not Applicable
NCT04207359	The University of Texas Health Science Center at San Antonio\|The Claude D. Pepper Older Americans Independence Centers	Breast Cancer\|Chemotherapy Effect\|Muscle Weakness\|Muscle Loss\|Exercise	September 30, 2020	Not Applicable
NCT01411150	Massachusetts General Hospital\|National Institutes of Health (NIH)	Huntington´s Disease	May 2009	Phase 2
NCT00465140	University of Sao Paulo	Renal Insufficiency	January 2004	Not Applicable
NCT00070993	National Center for Complementary and Integrative Health (NCCIH)\|Office of Dietary Supplements (ODS)	Amyotrophic Lateral Sclerosis	December 2002	Phase 2
NCT02519751	GlaxoSmithKline	Sports Nutritional Sciences	October 2014	Not Applicable
NCT02058654	GlaxoSmithKline	Nutritional Status	December 1, 2013	Phase 1
NCT00473902	Hamilton Health Sciences Corporation\|McMaster University	Sarcopenia	August 2003	Not Applicable
NCT00712426	Massachusetts General Hospital\|University of Rochester\|National Center for Complementary and Integrative Health (NCCIH)	Huntington´s Disease	September 2009	Phase 3
NCT03000582	Texas A&M University\|Nutrabolt	Dietary Modification	June 2014	Not Applicable
NCT01890382	University of Sao Paulo	Frail Elderly Syndrome	October 1, 2015	Not Applicable
NCT01411163	Massachusetts General Hospital\|National Institutes of Health (NIH)	Huntington´s Disease	April 2010	Phase 2
NCT03224780	Beni-Suef University	Placenta Accreta	June 1, 2017
NCT01050556	Columbia University\|National Cancer Institute (NCI)	High Blood Arsenic Due to Chronic Arsenic Exposure	September 2010	Phase 4
NCT05014659	Florida State University	Endothelial Dysfunction\|Oxidative Stress	October 17, 2020	Not Applicable
NCT01514630	Perry Renshaw\|University of Utah	Depression\|Substance Abuse\|Substance Use\|Neuroimaging\|Dual Diagnosis	January 2013	Phase 4
NCT00081250	Alliance for Clinical Trials in Oncology\|National Cancer Institute (NCI)	Anorexia\|Cachexia\|Unspecified Adult Solid Tumor, Protocol Specific\|Weight Changes	December 2004	Phase 3
NCT03186053	Chinese Academy of Medical Sciences, Fuwai Hospital	Heart Valve Diseases	June 15, 2017	Not Applicable
NCT02961972	National Institute of Cardiology, Laranjeiras, Brazil	Endothelial Dysfunction\|Hyperhomocysteinemia	January 2015	Not Applicable
NCT02661334	David Grant U.S. Air Force Medical Center	Physical Fitness	August 1, 2015	Not Applicable
NCT01817673	University of Sao Paulo	Healthy Persons	July 2011	Not Applicable
NCT04058002	University of Sao Paulo General Hospital	Knee Osteoarthritis	August 15, 2019	Not Applicable
NCT02568878	Montana State University	Depression\|Anxiety\|Methamphetamine Dependence	November 2015	Phase 3
NCT02945241	Mayo Clinic	Methicillin-resistant Staphylococcus Aureus\|Sepsis\|Critical Illness	April 2014	Phase 1
NCT03202095	University of Utah	Major Depressive Disorder	August 1, 2017	Phase 4
NCT04286178	The Hospital for Sick Children	Myositis, Juvenile	April 6, 2021	Not Applicable
NCT01767844	Bangor University	Rheumatoid Arthritis	January 2013	Not Applicable
NCT02192931	Perry Renshaw\|University of Utah	Depression\|Dual Diagnosis\|Drug Addiction	September 2014	Phase 4
NCT05589064	Universite de Moncton\|New Brunswick Health Research Foundation	Brain Injury Traumatic Mild	October 2022	Not Applicable
NCT01025518	Danish Head and Neck Cancer Group\|Danish Center for Interventional Research in Radiation Oncology (CIRRO)	Head and Neck Neoplasms	September 2009	Not Applicable
NCT00449865	University of Rochester\|National Institute of Neurological Disorders and Stroke (NINDS)	Parkinson´s Disease	March 2007	Phase 3
NCT00016653	Cooperative International Neuromuscular Research Group	Muscular Dystrophy, Duchenne	June 2000	Phase 2\|Phase 3
NCT04395183	University of Utah	Major Depressive Disorder	March 1, 2021	Phase 2
NCT04086381	Maastricht University	Diet-induced Thermogenesis\|Brown Adipose Tissue Activation	May 1, 2018	Not Applicable
NCT01257581	Nazem Atassi\|ALS Therapy Alliance\|State University of New York - Upstate Medical University\|Massachusetts General Hospital	Amyotrophic Lateral Sclerosis	March 2011	Phase 2
NCT00063193	University of Rochester\|National Institute of Neurological Disorders and Stroke (NINDS)	Parkinson´s Disease	May 2003	Phase 2
NCT04423432	Foundation University Islamabad\|Isra University	Knee Osteoarthritis	January 1, 2020	Not Applicable
NCT01412151	Massachusetts General Hospital	Huntington´s Disease (HD)	April 2005	Phase 2
NCT02189915	Perry Renshaw\|University of Utah	Depression\|Dual Diagnosis\|Substance Use	January 2012	Not Applicable
NCT02922725	Brent Michael Kious, MD, PhD\|University of Utah	Major Depressive Disorder	November 2016	Phase 4
NCT03352128	Vrije Universiteit Brussel	Healthy\|Creatine Supplementation	September 10, 2018	Not Applicable

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H ₂ O : 6.25 mg/mL ( 47.66 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.6254 mL	38.1272 mL	76.2544 mL
5 mM	1.5251 mL	7.6254 mL	15.2509 mL
10 mM	0.7625 mL	3.8127 mL	7.6254 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 20 mg/mL (152.51 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

* All of the co-solvents are available by MCE.

References

[1] Nouioua S, et al. Creatine deficiency syndrome. A treatable myopathy due to arginine-glycine amidinotransferase (AGAT) deficiency. Neuromuscul Disord. 2013 Aug;23(8):670-4.

Synonyms

Glycine, N-(aminoiminomethyl)-N-methyl-

Creatine

N-(Aminoiminomethyl)-N-methylglycine

N-Methyl-N-guanylglycine

Methylguanidoacetic acid

Phosphagen

NSC 8752

Cosmocair C 100

Tego Cosmo C 100

Neotine

Kre-Alkalyn

[N-(Amidino)-N-methylamino]acetic acid

2-(1-Methylguanidino)acetic acid

(N-Methyl-guanidino)-acetic acid

2-[(C-Azaniumylcarbonimidoyl)-methylamino]acetate

2-(N-Methylcarbamimidamido)acetic acid