[CAS NO. 58-28-6] Desipramine hydrochloride
PRODUCTS SPECIFICATIONS [58-28-6]
DESCRIPTION [58-28-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 302.84 |
| Molecular Formula | C18H23ClN2 |
| SMILES | CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31.[H]Cl |
6 Publications Citing Use of MCE
Summary
Desipramine hydrochloride is an inhibitor of norepinephrine transporter ( NET ), 5-HT transporter ( SERT ) and dopamine transporter ( DAT ) with K i s of 4, 61 and 78,720 nM, respectively.
IC50 & Target
Ki: 4 nM (NET), 61 nM (SERT), 78720 nM (DAT) [1]
In Vivo
Treatment of rats with Desipramine hydrochloride for 14 days reduces norepinephrine transporter (NET) expression in a dose-dependent manner, as indicated by a reduction of the specific binding of 3 H-nisoxetine to the NET in preparations of cerebral cortex (F (3,16) =4.33, p<0.05) and hippocampus (F (3,16) =4.34, p<0.05). This NET down regulation is observed 2 days after discontinuation of chronic Desipramine hydrochloride treatment, a time when plasma and brain concentrations of Desipramine hydrochloride and desmethyldesipramine are undetectable (ie below the 25 ng detection limit of the assay) [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 330.21 mM )
H 2 O : 100 mg/mL ( 330.21 mM ; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3021 mL | 16.5104 mL | 33.0207 mL |
| 5 mM | 0.6604 mL | 3.3021 mL | 6.6041 mL |
| 10 mM | 0.3302 mL | 1.6510 mL | 3.3021 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (8.26 mM); Clear solution
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3.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (8.26 mM); Clear solution
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4.
Add each solvent one by one: PBS
Solubility: 1 mg/mL (3.30 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
References
- [1] Torres GE, et al. Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci. 2003 Jan;4(1):13-25.
- [2] Zhao Z, et al. Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. Neuropsychopharmacology. 2008 Dec;33(13):3190-200.
Synonyms