[CAS NO. 58-94-6] Chlorothiazide
PRODUCTS SPECIFICATIONS [58-94-6]
DESCRIPTION [58-94-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 295.72 |
| Molecular Formula | C7H6ClN3O4S2 |
| SMILES | O=S(C1=C(Cl)C=C(C2=C1)N=CNS2(=O)=O)(N)=O |
2 Publications Citing Use of MCE
Summary
Chlorothiazide is an orally active diuretic and anti-hypertensive agent [1] .
In Vitro
Chlorothiazide has a plasma half-life of 45–120 min and a biological half-life of nearly 10 h [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02546583 | Yale University|National Heart, Lung, and Blood Institute (NHLBI) |
Heart Failure
|
August 31, 2015 | Phase 1 |
| NCT00000484 | National Heart, Lung, and Blood Institute (NHLBI) |
Cardiovascular Diseases|Heart Diseases|Hypertension|Vascular Diseases
|
April 1966 | Phase 3 |
| NCT03574857 | University of Virginia |
Heart Failure|Heart Failure With Reduced Ejection Fraction|Heart Failure Acute|Cardiovascular Diseases
|
June 1, 2018 | Phase 4 |
| NCT02606253 | Vanderbilt University|Vanderbilt University Medical Center |
Heart Failure
|
February 2016 | Phase 4 |
| NCT00004360 | National Center for Research Resources (NCRR)|Northwestern University|Office of Rare Diseases (ORD) |
Diabetes Insipidus, Nephrogenic
|
September 1995 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 338.16 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3816 mL | 16.9079 mL | 33.8158 mL |
| 5 mM | 0.6763 mL | 3.3816 mL | 6.7632 mL |
| 10 mM | 0.3382 mL | 1.6908 mL | 3.3816 mL |
Synonyms