[CAS NO. 58142-99-7] DSRM-3716
PRODUCTS SPECIFICATIONS [58142-99-7]
DESCRIPTION [58142-99-7]
Overview
| MDL | MFCD11226893 |
|---|---|
| Molecular Weight | 255.06 |
| Molecular Formula | C9H6IN |
| SMILES | IC1=CC=CC2=C1C=CN=C2 |
Summary
DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC 50 of 75 nM. DSRM-3716 is selective against other NAD + -processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection [1] .
IC50 & Target
IC50: 75 nM (SARM1 NADase) [1]
In Vitro
DSRM-3716 treatment produces dose-dependent inhibition of cADPR increase (IC
50
of 2.8 μM) and substantial preservation of NAD
+
in these cultures in a manner consistent with engagement and inhibition of SARM1 enzymatic NADase activity inside the cells
[1]
.
DSRM-3716 prevents neurofilament light chain (NfL) release from severed axons in a dose-dependent manner, with an IC
50
of ~2 μM
[1]
.
The potency of DSRM-3716 to inhibit cADPR increase caused by axotomy (IC
50
of 2.8 μM) is similar to the potency required to prevent axonal degeneration (IC
50
of 2.1 μM)
[1]
.
DSRM-3716 inhibits the SARM1-dependent cell destruction pathway triggered by Rotenone in sensory neurons
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL ( 196.03 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.9206 mL | 19.6032 mL | 39.2065 mL |
| 5 mM | 0.7841 mL | 3.9206 mL | 7.8413 mL |
| 10 mM | 0.3921 mL | 1.9603 mL | 3.9206 mL |
Synonyms