[CAS NO. 58337-38-5] EHNA hydrochloride

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PRODUCTS SPECIFICATIONS [58337-38-5]

Catalog

HY-103160A

Brand

MCE

CAS

58337-38-5

DESCRIPTION [58337-38-5]

Overview

MDL	-
Molecular Weight	313.83
Molecular Formula	C14H24ClN5O
SMILES	CCCCCC[C@@](N1C2=C(C(N)=NC=N2)N=C1)([H])[C@H](O)C.[Relative stereochemistry].Cl

For research use only. We do not sell to patients.

3 Publications Citing Use of MCE

Summary

EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) ( IC ₅₀ =4 μM) and adenosine deaminase (ADA) . EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)( IC ₅₀ :0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects ^[1] ^[2] .

IC50 & Target

hPDE2A

0.8 μM (IC ₅₀ )

In Vitro

EHNA completely ablates the ability of cyclic GMP to activate PDE2 activity, whilst having a much smaller inhibitory effect on the unstimulated PDE2 activity ^[2] .
EHNA exhibits normal Michaelian kinetics of inhibition for the cyclic GMP-stimulated PDE2 activity with Hill plots near unity ^[2] .
EHNA prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 250 mg/mL ( 796.61 mM )

H ₂ O : 100 mg/mL ( 318.64 mM ; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1864 mL	15.9322 mL	31.8644 mL
5 mM	0.6373 mL	3.1864 mL	6.3729 mL
10 mM	0.3186 mL	1.5932 mL	3.1864 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (6.63 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (6.63 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (6.63 mM); Clear solution

* All of the co-solvents are available by MCE.