[CAS NO. 58479-68-8] Platycodin D
PRODUCTS SPECIFICATIONS [58479-68-8]
DESCRIPTION [58479-68-8]
Overview
| MDL | MFCD09952590 |
|---|---|
| Molecular Weight | 1225.32 |
| Molecular Formula | C57H92O28 |
| SMILES | O=C([C@]1(CCC(C)(C)C2)[C@]2([H])C3=CC[C@@]4([H])[C@@](C)(CC[C@]5([H])[C@@]4(C[C@H](O)[C@H](O[C@]([C@@H]([C@@H](O)[C@@H]6O)O)([H])O[C@@H]6CO)C5(CO)CO)C)[C@]3(C)C[C@H]1O)O[C@H](OC[C@H](O)[C@@H]7O)[C@@H]7O[C@@](O[C@@H](C)[C@H](O[C@@](OC[C@@H](O)[C@@H]8O[C@@](OC[C@]9(O)CO)([H])[C@@H]9O)([H])[C@@H]8O)[C@H]%10O)([H])[C@@H]%10O |
1 Publications Citing Use of MCE
Summary
IC50 & Target
AMPKα [1]
In Vitro
Platycodin D (4 μM; 24 h) increases gene expressions of Ucp1, Pgc1a, Sirt3, Cytc, Nrf1 and Prdm16, and suppresses expressions of adipokine genes Fabp4, Adipoq, Lipin1 in 3T3-L1 adipocytes and FABP4, ADIPOQ and RESISTIN in hAMSCs
[1]
.
Platycodin D (2 and 10 μM) suppresses lipid accumulation in murine and human adipocytes respectively
[1]
.
Platycodin D suppresses the protein expressions of PPARγ and C/EBPα, and increases protein expressions of UCP1, PGC1α, SIRT3, CIDEA and LIPIN1
[1]
.
Platycodin D (10 μM) inhibits lipid droplet formation, and reduces the expression of the FABP4 protein involved in lipid metabolism and the expressions of PPARγ and C/EBPα
[2]
.
Platycodin D (10 μM; 0-7 d) recoveres CCND1 mRNA level and increases PPARδ level
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Platycodin D (5 mg/kg; oral administration, 5 times per week for 5 weeks) decreases the body weight of obese mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Genetically obese db/db mice [1] |
| Dosage: | 5 mg/kg |
| Administration: | Oral administration; 5 mg/kg, 5 times per week for 5 weeks |
| Result: | Significantly decreased body weight gain without affecting food intake of mice. Decreased the liver tissue weight and increased the weight of brown adipose tissue (BAT). |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 40.81 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.8161 mL | 4.0806 mL | 8.1611 mL |
| 5 mM | 0.1632 mL | 0.8161 mL | 1.6322 mL |
| 10 mM | 0.0816 mL | 0.4081 mL | 0.8161 mL |
References
- [1] Kim HL, et al. Platycodin D, a novel activator of AMP-activated protein kinase, attenuates obesity in db/db mice via regulation of adipogenesis and thermogenesis. Phytomedicine. 2019 Jan;52:254-263.
- [2] Lee H, et al. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D, a natural compound found in Platycodon grandiflorum. Life Sci. 2011 Sep 12;89(11-12):388-94.
Synonyms