[CAS NO. 58880-19-6] TrichostatinA

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PRODUCTS SPECIFICATIONS [58880-19-6]

Catalog

HY-15144

Brand

MCE

CAS

58880-19-6

DESCRIPTION [58880-19-6]

Overview

MDL	MFCD03848392
Molecular Weight	302.37
Molecular Formula	C17H22N2O3
SMILES	CN(C1=CC=C(C=C1)C([C@@H](/C=C(/C=C/C(NO)=O)C)C)=O)C

For research use only. We do not sell to patients.

77 Publications Citing Use of MCE

Summary

Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II , with an IC ₅₀ value of 1.8 nM for HDAC ^[1] .

IC50 & Target

HDAC

1.8 nM (IC ₅₀ )

In Vitro

Trichostatin A is a potent and specific inhibitor of HDAC class I/II, with an IC ₅₀ value of 1.8 nM for HDAC. Trichostatin A (TSA) inhibits proliferation of eight breast carcinoma cell lines with mean±SD IC ₅₀ of 124.4±120.4 nM (range, 26.4-308.1 nM). HDAC inhibitory activity of Trichostatin A is similar in all cell lines with mean IC ₅₀ of 2.4±0.5 nM (range, 1.5-2.9 nM) ^[1] . Trichostatin A (330 nM) increases Gαs protein expression in human myometrial cells, but does not increase Gαs mRNA levels ^[2] . Trichostatin A (20-75 nM) induces minimal cytotoxicity to adipose-derived stem cells (ADSCs), and enhances the osteogenic differentiation capacity of ADSCs ^[3] . In addition, Trichostatin A (0, 10, 100, 500 nM) dose-dependently decreases HDAC class I/II activity ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Trichostatin A (500 μg/kg, s.c.) pronounces antitumor activity without causing any measurable toxicity in doses of up to 5 mg/kg by s.c. injection, in randomized controlled efficacy studies using the N-methyl-N-nitrosourea carcinogen-induced rat mammary carcinoma model ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 82.68 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3072 mL	16.5360 mL	33.0721 mL
5 mM	0.6614 mL	3.3072 mL	6.6144 mL
10 mM	0.3307 mL	1.6536 mL	3.3072 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (8.27 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution
3.

Add each solvent one by one: 5% DMSO >> 40% PEG300 >> 5% Tween-80 >> 50% saline

Solubility: 2.5 mg/mL (8.27 mM); Suspended solution; Need ultrasonic
4.

Add each solvent one by one: 5% DMSO >> 95% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)-

2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, [R-(E,E)]-

(2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

Trichostatin A

(R)-Trichostatin A

TSA

(R)-(+)-Trichostatin A