[CAS NO. 59-48-3] Oxindole
PRODUCTS SPECIFICATIONS [59-48-3]
DESCRIPTION [59-48-3]
Overview
| MDL | MFCD00005711 |
|---|---|
| Molecular Weight | 133.15 |
| Molecular Formula | C8H7NO |
| SMILES | O=C1NC2=C(C=CC=C2)C1 |
1 Publications Citing Use of MCE
Summary
Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.
IC50 & Target
|
Human Endogenous Metabolite |
In Vitro
Oxindole (Indolin-2-one) is a bicyclic structure consisting of a benzene ring fused to 2-pyrrolidone. Substituted indolinones can be referred as ‘privileged structures’ owing to their excellent binding affinity for many receptors and to the number of approved drugs containing this scaffold [1] . Oxindole has been found in tissues and fluids of mammals as well as natural products produced by a range of plants, bacteria and invertebrates. 2-indolinone derivatives possess diverse range of pharmacological activities including anti-cancer, anti-HIV, anti-diabetic, antibacterial, antioxidant, kinase inhibitory, AChE inhibitory, anti-leishmanial, b3 adrenergic receptor agonistic, phosphatase inhibitory, analgesic, spermicidal, vasopressin antagonists, progesterone antagonists, neuroprotection, NMDA blocker and sleep inducing activities [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 375.52 mM ; ultrasonic and warming and heat to 80°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 7.5103 mL | 37.5516 mL | 75.1033 mL |
| 5 mM | 1.5021 mL | 7.5103 mL | 15.0207 mL |
| 10 mM | 0.7510 mL | 3.7552 mL | 7.5103 mL |
References
Synonyms