[CAS NO. 599150-20-6] GLI antagonist-1
PRODUCTS SPECIFICATIONS [599150-20-6]
DESCRIPTION [599150-20-6]
Overview
| MDL | MFCD03312466 |
|---|---|
| Molecular Weight | 463.52 |
| Molecular Formula | C27H29NO6 |
| SMILES | COCCOC(C1=C(C)NC(CC(C2=C(C=CC=C2)OC)CC3=O)=C3C1C4=CC(O)=CC=C4)=O |
Summary
IC50 & Target
IC 50 : 1.1 µM (GLI) [1]
In Vitro
GLI antagonist-1 (compound HPI-1) (0-25 µM; 72 h) shows anti-proliferative activity with IC
50
values of 29, >25, 20.5 µM for SUM149, MDA-MB-231, SUM159 cells, respectively
[1]
.
GLI antagonist-1 (10 µM; 72 h) decreases the GLI1 mRNA expression in SUM149 cells
[1]
.
GLI antagonist-1 (5, 10, 20 µM) inhibits colony formation in a dose-dependent manner in SUM149 and MDA-MB-231 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [1]
| Cell Line: | SUM149, MDA-MB-231, SUM159 cells |
| Concentration: | 0-25 µM |
| Incubation Time: | 72 h |
| Result: | Showed anti-proliferative activity with IC 50 values of 29, >25, 20.5 µM for SUM149, MDA-MB-231, SUM159 cells, respectively. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |