[CAS NO. 605-62-9] KAT8-IN-1

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PRODUCTS SPECIFICATIONS [605-62-9]

Catalog

HY-W015239

Brand

MCE

CAS

605-62-9

DESCRIPTION [605-62-9]

Overview

MDL	MFCD02179392
Molecular Weight	189.17
Molecular Formula	C10H7NO3
SMILES	OC1=C2C=CC=CC2=C([N+]([O-])=O)C=C1

For research use only. We do not sell to patients.

Summary

KAT8-IN-1 is a lysine (K) acetyltransferase 8 ( KAT8 ) inhibitor, with IC ₅₀ s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases ^[1] .

IC50 & Target

IC50: 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B) ^[1]

In Vitro

KAT8-IN-1 (compound 19) losses anti-oxidant activity (EC ₅₀ >1 mM) ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 528.63 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2863 mL	26.4313 mL	52.8625 mL
5 mM	1.0573 mL	5.2863 mL	10.5725 mL
10 mM	0.5286 mL	2.6431 mL	5.2863 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1 mg/mL (5.29 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Wapenaar H, et al. The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. Eur J Med Chem. 2017 Aug 18;136:480-486.

Synonyms

1-Naphthalenol, 4-nitro-

1-Naphthol, 4-nitro-

4-Nitro-1-naphthalenol

1-Hydroxy-4-nitronaphthalene

4-Nitro-α-naphthol

4-Nitro-1-naphthol

4-Nitro-1-hydroxynaphthalene

NSC 400336