[CAS NO. 607-80-7] Sesamin

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PRODUCTS SPECIFICATIONS [607-80-7]

Catalog

HY-N0121

Brand

MCE

CAS

607-80-7

DESCRIPTION [607-80-7]

Overview

MDL	MFCD00216134
Molecular Weight	354.35
Molecular Formula	C20H18O6
SMILES	[H][C@@]12[C@@H](C3=CC=C(OCO4)C4=C3)OC[C@]1([H])[C@@H](C5=CC=C(OCO6)C6=C5)OC2

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Chem Biol Drug Des. 2021 Aug 19.

Summary

Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia ^[1] ^[2] .

IC50 & Target

delta 5 desaturase ^[1]

In Vitro

Pretreated with sesamin, Excess generation of nitric oxide in lipopolysaccharide-stimulated rat primary microglia cells was significantly attenuated ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sesamin (o.p.; 20 mg/kg/day) significantly reduces the infarct size by approximately 50% in male gerbils (60-85 g) ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 282.21 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8221 mL	14.1103 mL	28.2207 mL
5 mM	0.5644 mL	2.8221 mL	5.6441 mL
10 mM	0.2822 mL	1.4110 mL	2.8221 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

1,3-Benzodioxole, 5,5′-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-, (1S,3aR,4S,6aR)-

1,3-Benzodioxole, 5,5′-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-, [1S-(1α,3aα,4α,6aα)]-

1H,3H-Furo[3,4-c]furan, tetrahydro-1,4-bis[3,4-(methylenedioxy)phenyl]-, (1S,3aR,4S,6aR)-

1H,3H-Furo[3,4-c]furan, 1,3-benzodioxole deriv.

(1S,3aR,4S,6aR)-5,5′-(Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[1,3-benzodioxole]

Sesamin

Fagarol

Sesamin, (+)-

(+)-Sesamin

d-Sesamin

Tetrahydro-1,4-bis[3,4-(methylenedioxy)phenyl]-1H,3H-furo[3,4-c]furan

Sezamin

NSC 36403

Zengxiaomin

δ-Sesamin

Sesavita