[CAS NO. 61077-78-9] Tanshinone IIA anhydride

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PRODUCTS SPECIFICATIONS [61077-78-9]

Catalog

HY-N10686

Brand

MCE

CAS

61077-78-9

DESCRIPTION [61077-78-9]

Overview

MDL	-
Molecular Weight	310.34
Molecular Formula	C19H18O4
SMILES	CC1(CCCC2=C1C=CC3=C2C(OC(C4=C3OC=C4C)=O)=O)C

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Summary

Tanshinone IIA anhydride is a potent and irreversible human carboxylesterase (CE) inhibitor with K _i values of 1.9 nM and 1.4 nM for human CE1 and the human intestinal CE (hiCE), respectively ^[1] .

IC50 & Target

Ki: 1.9 nM (Human carboxylesterase (CE)) and 1.4 nM (human intestinal CE) ^[1]

Source

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] M Jason Hatfield, et al. Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza ("Danshen"). J Nat Prod. 2018 Nov 26;81(11):2410-2418.