[CAS NO. 61301-33-5] Schisandrin C

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PRODUCTS SPECIFICATIONS [61301-33-5]

Catalog

HY-N0690

Brand

MCE

CAS

61301-33-5

DESCRIPTION [61301-33-5]

Overview

MDL	-
Molecular Weight	384.42
Molecular Formula	C22H24O6
SMILES	[H][C@@]([C@](C)([H])C1)(C)CC2=CC3=C(C(OC)=C2C4=C1C=C5OCOC5=C4OC)OCO3

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

Schisandrin C (Schizandrin-C) is a phytochemical lignan isolated from Schizandra chinensis ^[1] . Schisandrin C has diverse biological activities, including anticancer, anti-inflammatory and antioxidant effects. Schisandrin C is a molecular glue. Schisandrin C can be used for cancer , alzheimer’s disease, and liver diseases research ^[2] ^[3] . Schisandrin C induces cell apoptosis ^[1] .

In Vitro

Schisandrin C (25-100 μM; 48 hours) down-regulates expression levels of Bcl-2, Bcl-xL and a concomitant degradation of poly(ADP-ribose) polymerase (PARP). It also activates caspase-3 and -9 in U937 cells ^[2] .
Schisandrin C (25-100 μM; 48 hours) induces apoptosis in a dose-dependent manner. And the fragmentation of genomic DNA is also increased in U937 cells ^[1] .
Schisandrin C (25-100 μM; 72 hours) induces G1 arrest, it down-regulates cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4 and E2Fs expression, and also exhibits inhibition of pRB, and up-regulation of the Cdk inhibitor p21(WAF1/CIP1) ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis ^[1]

Cell Line:	U937 cells
Concentration:	25 μM,50 μM,100 μM
Incubation Time:	48 hours
Result:	Decreased the expression of apoptosis related proteins.

Apoptosis Analysis ^[1]

Cell Line:	U937 cells
Concentration:	25 μM,50 μM,100 μM
Incubation Time:	48 hours
Result:	Induced cell apoptosis.

Cell Cycle Analysis ^[1]

Cell Line:	U937 cells
Concentration:	25 μM,50 μM,100 μM
Incubation Time:	48 hours
Result:	Induced growth inhibition and G1 arrest of U937 cells.

In Vivo

Schisandrin C (lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days) reduces Aβ1-42-induced memory deficits in the Y-maze test. Neurons in the hippocampus of SCH-C (15 μg/kg)-treated group returned to normal level, and and SCH-C group (150 μg/kg) has slight neuroprotective effects Aβ1-42-induced group. SCH-C (15 μg/kg) recoveres the activities of SOD and GSHPx and the ratios of GSH, decreases the levels of ChEtotal in the brain of the Aβ1–42-induced amnesic mice simultaneously ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Aβ1-42-induced Alzheimer’s disease mice ^[3]
Dosage:	15-150 μg/kg
Administration:	Lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days
Result:	Exhibited potent neuroprotective effects linking to anti-ChEtotal activities and anti-oxidative mechanisms in Aβ1-42-induced amnestic mice.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 8.33 mg/mL ( 21.67 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6013 mL	13.0066 mL	26.0132 mL
5 mM	0.5203 mL	2.6013 mL	5.2026 mL
10 mM	0.2601 mL	1.3007 mL	2.6013 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 0.83 mg/mL (2.16 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 0.83 mg/mL (2.16 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Cycloocta[1,2-f:3,4-f′]bis[1,3]benzodioxole, 5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl-, (6R,7S,13aS)-

Cycloocta[1,2-f:3,4-f′]bis[1,3]benzodioxole, 5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl-, stereoisomer

(6R,7S,13aS)-5,6,7,8-Tetrahydro-13,14-dimethoxy-6,7-dimethylcycloocta[1,2-f:3,4-f′]bis[1,3]benzodioxole

Wuweizisu C

Schizandrin C

Schisandrin C

(-)-Wuweizisu C

(S)-(-)-Schisandrin C

(-)-Schisandrin C