[CAS NO. 61422-45-5] Carmofur

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PRODUCTS SPECIFICATIONS [61422-45-5]

Catalog

HY-B0182

Brand

MCE

CAS

61422-45-5

DESCRIPTION [61422-45-5]

Overview

MDL	MFCD00866284
Molecular Weight	257.26
Molecular Formula	C11H16FN3O3
SMILES	O=C(N(C(N1)=O)C=C(F)C1=O)NCCCCCC

For research use only. We do not sell to patients.

3 Publications Citing Use of MCE

Summary

Carmofur (HCFU), a derivative of 5-Fluorouracil, is an antineoplastic agent. Carmofur is an inhibitor of acid ceramidase with an IC ₅₀ of 79 nM for the rat enzyme. Carmofur inhibits the SARS-CoV-2 main protease (Mpro). Carmofur Inhibits SARS-CoV-2 in Vero E6 cell with an EC ₅₀ of 24.3 μM ^[1] ^[2] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 388.71 mM )

H ₂ O : 0.67 mg/mL ( 2.60 mM ; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8871 mL	19.4356 mL	38.8712 mL
5 mM	0.7774 mL	3.8871 mL	7.7742 mL
10 mM	0.3887 mL	1.9436 mL	3.8871 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.08 mg/mL (8.09 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (8.09 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (8.09 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

1(2H)-Pyrimidinecarboxamide, 5-fluoro-N-hexyl-3,4-dihydro-2,4-dioxo-

5-Fluoro-N-hexyl-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinecarboxamide

1-(Hexylcarbamoyl)-5-fluorouracil

1-(n-Hexylcarbamoyl)-5-fluorouracil

HCFU

1-(Hexylcarbamyl)-5-fluorouracil

Carmofur

Mifurol

Yamaful