[CAS NO. 62-32-8] N-Methyldopamine hydrochloride
PRODUCTS SPECIFICATIONS [62-32-8]
DESCRIPTION [62-32-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 203.67 |
| Molecular Formula | C9H14ClNO2 |
| SMILES | CNCCC1=CC(O)=C(O)C=C1.Cl |
Summary
N-Methyldopamine hydrochloride is a precursor of adrenaline in the adrenal medulla. N-Methyldopamine hydrochloride is a modification of the dopamine (DA), and retains agonist activity at the DA1 receptor . N-Methyldopamine hydrochloride remains capable of universal surface coating and secondary reactions using the surface catechols. N-Methyldopamine hydrochloride can be used for heart failure research [1] [2] [3] .
IC50 & Target
|
D 1 Receptor |
In Vitro
N-Methyldopamine hydrochloride shows highly improved surface coating properties, and exhibits an accelerated coating rate. N-Methyldopamine hydrochloride coating makes solid surface cell adhesion possible, and postfunctionalization of the coating is also possible [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 125 mg/mL ( 613.74 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.9099 mL | 24.5495 mL | 49.0990 mL |
| 5 mM | 0.9820 mL | 4.9099 mL | 9.8198 mL |
| 10 mM | 0.4910 mL | 2.4550 mL | 4.9099 mL |
References
- [1] Kim Y, et al. Effect of N-Methylation on Dopamine Surface Chemistry. Langmuir. 2022 May 24;38(20):6404-6410.
- [2] Laduron P. N-Methyldopamine (epinine), a precursor of adrenaline in the adrenal medulla. Arch Int Pharmacodyn Ther. 1972 Apr;196:Suppl 196:304-.
- [3] Rajfer SI, et al. Effects of long-term therapy with oral ibopamine on resting hemodynamics and exercise capacity in patients with heart failure: relationship to the generation of N-methyldopamine and to plasma norepinephrine levels. Circulation. 1986 Apr;
Synonyms